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Carla A. Borgoño
Researcher at University of Toronto
Publications - 33
Citations - 2969
Carla A. Borgoño is an academic researcher from University of Toronto. The author has contributed to research in topics: Kallikrein & Ovarian cancer. The author has an hindex of 25, co-authored 33 publications receiving 2874 citations. Previous affiliations of Carla A. Borgoño include Mount Sinai Hospital & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
The emerging roles of human tissue kallikreins in cancer.
TL;DR: Human tissue kallikreins, which are encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles that might represent attractive targets for therapeutic intervention.
Journal Article
Human tissue kallikreins: physiologic roles and applications in cancer.
TL;DR: Many kallikreins, in addition to hK3/PSA, have been identified as promising diagnostic and/or prognostic biomarkers for several cancer types, including ovarian, breast, and prostate.
Journal ArticleDOI
A Potential Role for Multiple Tissue Kallikrein Serine Proteases in Epidermal Desquamation
Carla A. Borgoño,Iacovos P. Michael,Nahoko Komatsu,Arumugam Jayakumar,Ravi Kapadia,Gary L. Clayman,Georgia Sotiropoulou,Eleftherios P. Diamandis +7 more
TL;DR: It is indicated that multiple KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI and these findings may have clinical implications for the treatment of skin disorders in which KLK activity is elevated.
Journal ArticleDOI
Human tissue kallikreins: the cancer biomarker family.
Miltiadis Paliouras,Carla A. Borgoño,Carla A. Borgoño,Eleftherios P. Diamandis,Eleftherios P. Diamandis,Eleftherios P. Diamandis +5 more
TL;DR: The identification of kallikrein substrates and the development of proteolytic cascade models implicate kallkrein proteins in cancer progression, and the current status of k allikreins as cancer biomarkers is described.
Journal Article
Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer.
George M. Yousef,Mary Ellen Polymeris,Linda Grass,Antoninus Soosaipillai,Pak Cheung Chan,Andreas Scorilas,Carla A. Borgoño,Nadia Harbeck,Barbara Schmalfeldt,Julia Dorn,Manfred Schmitt,Eleftherios P. Diamandis +11 more
TL;DR: The preliminary data indicate that hK5 is a potential biomarker in patients with ovarian and breast cancer, and a sandwich-type microplate immunoassay (ELISA) was developed using these antibodies, coupled with a time-resolved fluorometric detection technique.