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Antonio De Maio
Researcher at University of California, San Diego
Publications - 113
Citations - 3937
Antonio De Maio is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Heat shock protein & Sepsis. The author has an hindex of 31, co-authored 111 publications receiving 3579 citations. Previous affiliations of Antonio De Maio include University of California, Los Angeles & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages
Virginia L. Vega,Monica Rodríguez-Silva,Tiffany Frey,Mathias Gehrmann,Juan Carlos Diaz,Claudia Steinem,Gabriele Multhoff,Nelson Arispe,Antonio De Maio,Antonio De Maio +9 more
TL;DR: It is shown that Hsp70 integrates into artificial lipid bilayer openings of ion conductance pathways and is released within membranous structures from intact cells, which could act as a danger signal to activate the immune system.
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Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa.
TL;DR: The term Stress Observation System (SOS) is coined for the mechanism for sensing extracellular hsp, which is a form of cellular communication during stress conditions and which is likely to act as indicators of the stress conditions, priming other cells to avoid the propagation of the insult.
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Tumor-Specific Hsp70 Plasma Membrane Localization Is Enabled by the Glycosphingolipid Gb3
Mathias Gehrmann,Gerhard Liebisch,Gerd Schmitz,Robin L. Anderson,Claudia Steinem,Antonio De Maio,Graham Pockley,Gabriele Multhoff +7 more
TL;DR: Global lipid profiling demonstrates that Hsp70 membrane-positive tumors differ from their membrane-negative counterparts by containing significantly higher amounts of globotriaoslyceramide (Gb3), but not of other lipids such as lactosylceramide (LacCer) or the ganglioside GM1, and confirms that Gb3 is an interaction partner for HSP70.
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Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability
TL;DR: It is shown that Hsp70 and Hsc70 display a highly selective interaction with phosphatidylserine moieties on membranes, followed by rapid incorporation into the lipid bilayer, suggesting that the presence of HSp70 in the extracellular medium may be an accelerator of apoptosis.
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Gap junctions, homeostasis, and injury.
TL;DR: The alteration of Gj communication during injury is proposed to attenuates the spread of toxic metabolites from the injured area to healthy organ regions and reduces the loss of important cellular metabolisms, such as ATP and glucose.