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Antonio Lapenna
Researcher at University of Sheffield
Publications - 5
Citations - 250
Antonio Lapenna is an academic researcher from University of Sheffield. The author has contributed to research in topics: Liver X receptor & Protein kinase B. The author has an hindex of 5, co-authored 5 publications receiving 137 citations.
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Journal ArticleDOI
Perivascular macrophages in health and disease
TL;DR: The functions of a specialized population of macrophages that make direct contact with or are found within one cell thickness of the abluminal surface of blood vessels in various tissues during both steady-state conditions and pathological processes are examined.
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Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer.
TL;DR: The results confirm that Xanthotoxol has the best docking score for breast cancer followed by Bergapten, Angelicin, Psoralen and Isoimperatorin, and validate the molecular docking analysis.
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Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways
Shakti Prasad Pattanayak,Pritha Bose,Priyashree Sunita,Mohd Usman Mohd Siddique,Antonio Lapenna +4 more
TL;DR: Evidence is provided and the critical role of BeG in maintaining the lipid homeostasis is validated and justifies its anticancer potential against NDEA-induced HCC.
Journal ArticleDOI
Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway.
Md. Wasimul Haque,Pritha Bose,Mohd Usman Mohd Siddique,Priyashree Sunita,Antonio Lapenna,Shakti Prasad Pattanayak +5 more
TL;DR: Taxifolin (TAX) modulated the energy regulation on DMBA-induced MC in SD-rats by significantly restoring the cancer-induced alterations in body weight, tumor growth and lipid, lipoproteins, lipid metabolizing enzymes and glycolytic enzymes.
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Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Pritha Bose,Mohd Usman Mohd Siddique,Reetuparna Acharya,Venkatesan Jayaprakash,Barij Nayan Sinha,Antonio Lapenna,Shakti Prasad Pattanayak +6 more
TL;DR: The potency of BNUA‐3 is demonstrated in efficient restoration of the altered morphology of liver, its protective effect against lipid peroxidation, enzymic and non‐enzymic antioxidants levels in liver tissue which was disrupted after cancer induction and the chemotherapeutic potency of AhR/CYP1B1/Nrf2/Keap1 pathway is revealed.