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Shinu Chacko
Researcher at Birla Institute of Technology, Mesra
Publications - 4
Citations - 171
Shinu Chacko is an academic researcher from Birla Institute of Technology, Mesra. The author has contributed to research in topics: Docking (molecular) & Hepatocellular carcinoma. The author has an hindex of 4, co-authored 4 publications receiving 104 citations. Previous affiliations of Shinu Chacko include Government Medical College, Thiruvananthapuram.
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Journal ArticleDOI
Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer.
TL;DR: The results confirm that Xanthotoxol has the best docking score for breast cancer followed by Bergapten, Angelicin, Psoralen and Isoimperatorin, and validate the molecular docking analysis.
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“Hepatocellular carcinoma: A life-threatening disease”
Shinu Chacko,Subir Samanta +1 more
TL;DR: The reported data shows that the rate of HCC incidence in male population is three to four times higher compared with the female population, and in the United States, HCV-induced liver cancer is increasing very fast because of the lack of proper treatment option.
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A novel approach towards design, synthesis and evaluation of some Schiff base analogues of 2-aminopyridine and 2-aminobezothiazole against hepatocellular carcinoma
Shinu Chacko,Subir Samanta +1 more
TL;DR: Findings suggested that SSSC-33-((benzo[d]thiazol-2-ylimino) methyl)phenol) could be a potential compound in combating the oxidative damage of hepatic cells occurred due to the development of hepatocellular carcinoma induced by a chemical carcinogen, DEN.
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Novel Thiosemicarbazide Hybrids with Amino Acids and Peptides Against Hepatocellular Carcinoma: A Molecular Designing Approach Towards Multikinase Inhibitor.
Shinu Chacko,Subir Samanta +1 more
TL;DR: It was found that conjugation with amino acids decreases toxicity and increases the therapeutic index of thiosemicarbazide, and the efficacy of designed compounds against hepatocellular carcinoma needs to be confirmed by wet lab synthesis, in vitro ADMET and biological screening studies.