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Antony J. Workman
Researcher at University of Glasgow
Publications - 39
Citations - 1558
Antony J. Workman is an academic researcher from University of Glasgow. The author has contributed to research in topics: Effective refractory period & Atrial action potential. The author has an hindex of 19, co-authored 38 publications receiving 1420 citations. Previous affiliations of Antony J. Workman include British Heart Foundation & Glasgow Royal Infirmary.
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Journal ArticleDOI
Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
Eleonora Grandi,Sandeep V. Pandit,Niels Voigt,Antony J. Workman,Dobromir Dobrev,José Jalife,Donald M. Bers +6 more
TL;DR: In this article, the authors developed a new human atrial action potential (AP) model, derived from atrial experimental results and our human ventricular myocyte model, and showed how Na + and Ca 2+ homeostases critically mediate abnormal repolarization in AF.
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The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation
TL;DR: Chronic AF in humans is associated with attenuation in adaptation of the atrial single cell ERP and MDP to fast rates, which may not be explained fully by accompanying changes in I(CaL) and I(TO).
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Cardiac adrenergic control and atrial fibrillation
TL;DR: An improved understanding of the involvement of the adrenergic system and its control in basic mechanisms of AF under differing cardiac pathologies might lead to better treatments.
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Cellular bases for human atrial fibrillation
TL;DR: The search for drugs to suppress AF without causing ventricular arrhythmias has been aided by basic studies of cellular mechanisms of AF, and it remains to be seen whether such drugs will improve patient treatment.
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A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso.
Erick A. Perez Alday,Michael A. Colman,Philip Langley,Timothy D. Butters,Jonathan Higham,Antony J. Workman,Jules C. Hancox,Henggui Zhang +7 more
TL;DR: A recently developed 3D human atrial model is applied to simulate electrical activity during normal sinus rhythm and ectopic pacing to identify the origin of atrial ectopic activity from the electrocardiogram (ECG) and an algorithm to obtain the location of the stimulus from a 64-lead ECG system was developed.