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April M. Handy
Researcher at National Institutes of Health
Publications - 10
Citations - 1470
April M. Handy is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Calorie restriction & Bone remodeling. The author has an hindex of 9, co-authored 10 publications receiving 1374 citations. Previous affiliations of April M. Handy include Blackburn College & Charles River Laboratories.
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Journal ArticleDOI
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Julie A. Mattison,George S. Roth,T. Mark Beasley,Edward M. Tilmont,April M. Handy,April M. Handy,Richard Herbert,Dan L. Longo,David B. Allison,Jennifer E. Young,Mark Bryant,Dennis Barnard,Walter F. Ward,Wenbo Qi,Donald K. Ingram,Rafael de Cabo +15 more
TL;DR: A separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate is suggested.
Journal ArticleDOI
Caloric Restriction in Primates
TL;DR: Conclusive evidence showing that CR extends life span in primates is not presently available; however, the emerging data from the ongoing primate studies strengthens the possibility that the diverse beneficial effects of CR on aging in rodents will also apply to nonhuman primates and perhaps ultimately to humans.
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Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta).
Mark A. Lane,Edward M. Tilmont,Holly De Angelis,April M. Handy,Donald K. Ingram,Joseph W. Kemnitz,George S. Roth +6 more
TL;DR: Interestingly, the observed glucoregulatory changes emerged prior to any evidence of a change in body composition suggesting that certain effects of CR may not be wholly dependent on changes inBody composition in older monkeys.
Journal ArticleDOI
Energy Restriction Does Not Alter Bone Mineral Metabolism or Reproductive Cycling and Hormones in Female Rhesus Monkeys
Mark A. Lane,A. Black,April M. Handy,Sue A. Shapses,Edward M. Tilmont,Tara L. Kiefer,Donald K. Ingram,George S. Roth +7 more
TL;DR: Examination of the effects of chronic (6 y) ER on skeletal and reproductive indices in 40 premenopausal and perimenopausal female rhesus macaques concludes that ER does not negatively affect these indices of skeletal or reproductive health and does not alter age-associated changes in the same variables.
Journal ArticleDOI
Effects of dietary caloric restriction and aging on thyroid hormones of rhesus monkeys.
George S. Roth,April M. Handy,J. A. Mattison,Edward M. Tilmont,Donald K. Ingram,Mark A. Lane +5 more
TL;DR: A possible mechanism by which CR diets may elicit their well-known beneficial 'anti-aging' effects in mammals is suggested.