Arash Hamidian

TL;DR: Novel insights are provided into how HIF2α expression is transcriptionally controlled by hypoxia and how this control is abrogated by inhibition of insulin-like growth factor-1R/INSR-driven phosphoinositide 3-kinase (PI3K) signaling.

TL;DR: Findings provide a rationale for the unexpected IGF2 expression in neuroblastomas and might suggest that IGF2 and HIF2A positive neuroblastoma cells are arrested at an embryonic differentiation stage corresponding to the stage when sympathetic chain ganglia begins to coalesce.

TL;DR: It is demonstrated that transcriptional regulation of Hif-2α seems to be restricted to neural cell-derived tumors, while HIF-1α is canonically regulated at the post-translational level uniformly across different tumor forms.

TL;DR: This work employs the novel CRISPR/Cas9-based engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) - mass spectrometry (MS) methodology to identify proteins that associate with the EPAS1 promoter under normoxic and hypoxic conditions and proposes a putative model where HDX negatively regulates EPAS 1 expression through a release-of-inhibition mechanism.

TL;DR: In this article , the authors used data from the National Swedish Lung Cancer Registry to evaluate 6183 patients diagnosed with NSCLC during 2016-2019 with reported NGS-based KRAS-status.