S
Sofie Mohlin
Researcher at Lund University
Publications - 37
Citations - 936
Sofie Mohlin is an academic researcher from Lund University. The author has contributed to research in topics: Neuroblastoma & Neural crest. The author has an hindex of 15, co-authored 32 publications receiving 623 citations. Previous affiliations of Sofie Mohlin include California Institute of Technology.
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Journal ArticleDOI
Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
Roni Allaoui,Caroline Bergenfelz,Sofie Mohlin,Catharina Hagerling,Catharina Hagerling,Kiarash Salari,Zena Werb,Robin L. Anderson,Stephen P. Ethier,Karin Jirström,Sven Påhlman,Daniel Bexell,Balázs Tahin,Martin Johansson,Christer Larsson,Karin Leandersson +15 more
TL;DR: It is proposed that this migratory feedback loop amplifies the formation of a reactive stroma, contributing to the aggressive phenotype of TN breast tumours and could help select more suitable therapies targeting the stromal component of these tumours.
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Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue
Martina M. De Santis,Martina M. De Santis,Hani N. Alsafadi,Sinem Tas,Deniz A. Bölükbas,Sujeethkumar Prithiviraj,Iran A. Silva,Margareta Mittendorfer,Chiharu Ota,John Stegmayr,Fatima Daoud,Melanie Königshoff,Karl Swärd,Jeffery A. Wood,Manlio Tassieri,Paul Bourgine,Sandra Lindstedt,Sofie Mohlin,Darcy E. Wagner,Darcy E. Wagner +19 more
TL;DR: RECM bioinks are a promising new approach for generating functional human tissue using 3D bioprinting and suppress the foreign body response, are pro‐angiogenic and support recipient‐derived de novo blood vessel formation across the entire graft thickness in a murine model of transplant immunosuppression.
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Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours.
Noémie Braekeveldt,Caroline Wigerup,David Gisselsson,Sofie Mohlin,My Merselius,Siv Beckman,Tord Jonson,Anna Börjesson,Torbjörn Backman,Irene Tadeo,Ana P. Berbegall,Ingrid Øra,Samuel Navarro,Rosa Noguera,Sven Påhlman,Daniel Bexell +15 more
TL;DR: Neuroblastoma patient‐derived xenografts (PDXs) by orthotopic implantation of viably cryopreserved or fresh tumour explants of patients with high risk neuroblastoma into immunodeficient mice serve as clinically relevant models for studying and targeting high‐risk metastatic neuroblastomas.
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PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma.
Sofie Mohlin,Arash Hamidian,Kristoffer von Stedingk,Esther Bridges,Caroline Wigerup,Daniel Bexell,Sven Påhlman +6 more
TL;DR: Novel insights are provided into how HIF2α expression is transcriptionally controlled by hypoxia and how this control is abrogated by inhibition of insulin-like growth factor-1R/INSR-driven phosphoinositide 3-kinase (PI3K) signaling.
Journal ArticleDOI
Hypoxia and hypoxia-inducible factors in neuroblastoma
Sven Påhlman,Sofie Mohlin +1 more
TL;DR: Non-conventional actions of Hif-2α are discussed, its putative role as a therapeutic target and the constraints it carries, as well as the importance of HIF-2 activity in a vascularized setting, the so-called pseudo-hypoxic state.