The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

There is now compelling experimental evidence for the existence of specific intra- and intermolecular bonding between seemingly closed-shell gold(I) centers (5d10) which manifests itself in all areas of gold chemistry. This “aurophilic interaction”, which had not been predicted by conventional valence theory, was found to be associated with binding energies in some cases exceeding even those of strong hydrogen bonds and therefore to be highly significant in co-determining molecular structure and dynamics. In high-level theoretical treatments the attraction is rationalized as a “super van der Waals bonding” based on particularly strong relativistic, dispersion and correlation effects (critical review, 265 references).

A briefing on aurophilicity.

Chemists today are increasingly fascinated by gold’s unique position in the family of elements. In this review, the author looks at important new results emerging from recent research in gold chemistry.

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The fascinating implications of new results in gold chemistry

Structural and functional evolution of metallacrowns.

Drugs: A review of promising novel corrosion inhibitors

Voltammetric analysis of Cu (II), Cd (II) and Zn (II) complexes and their cyclic voltammetry with several cephalosporin antibiotics.

Der 1:1-Komplex aus AgBr und Bis(diphenylphosphino)methan (dppm) kristallisiert in der orthorhombischen Raumgruppe Pna21 mit a = 1910(1), b = 2147(1) und c = 1858(1) pm (Z = 4). Seine Struktur besteht aus diskreten Bromid-Anionen und dreikernigen Kationen [Ag3Br2(dppm)3]+, deren Grundelement eine trigonale Bipyramide mit den Ag-Atomen in den aquatorialen und den Br-Atomen in den axialen Positionen ist. Jeder dppm-Ligand verbruckt eine Seite des Ag3-Dreiecks. Der 2:1-Komplex aus AgBr und Bis(diphenylphosphino)-methylamin (dppa) kristallisiert in der monoklinen Raumgruppe P21/c mit a = 1136,0(7), b = 1603,3(12), c = 1689,1 (12) pm und β = 122,36(4)° (Z = 4). Das Grundelement seiner Struktur ist eine tetragonale Bipyramide mit vier Ag-Atomen in den aquatorialen und zwei Bromid-Atomen in den axialen Positionen. Die AgAg-Kanten werden abwechselnd durch Br-Atome und dppa-Liganden uberbruckt. Allgemeine geometrische Beziehungen von Strukturparametern in Komplexen mit Diphosphinomethan und ahnlichen Liganden werden abgeleitet und diskutiert.



Contributions to the Structural Chemistry of Silver Halide-Diphosphinomethane and Related Complexes



The 1:1-complex of AgBr with bis(diphenylphosphino)methane (dppm) crystallizes in the orthorhombic space group Pna21 with a = 1910(1), b = 2147(1) and c = 1858(1) (Z = 4). Its structure consists of discrete bromide anions and trinuclear cations [Ag3Br2(dppm)3]+. The basic unit is a trigonal bipyramid with the Ag atoms in the equatorial and the Br atoms in the axial positions. Each dppm ligand bridges an edge of the Ag3 triangle. The 2:1-complex of AgBr with bis (diphenylphosphino)methylamine (dppa) crystallizes in the monoclinic space group P21/c with a = 1136.0(7), b = 1603.3(12), c = 1689.1(12) pm and β = 122.36(4)° (Z = 4). The basic unit of its structure is a tetragonal bipyramid with four Ag atoms in the equatorial and the bromine atoms in the axial positions. The AgAg edges are alternatingly bridged by bromine atoms and dppa ligands. Some general relations between structural parameters in complexes with diphosphinomethane and related ligands are deducted and discussed.

Beiträge zur Strukturchemie von Silberhalogenid-Diphosphinomethan- und verwandten Komplexen†

Ten mixed ligand complexes of the type [M(X-QA)(aa)] and [Ni(X-QA)2(Haa)(H2O)],where X-HQA=5-arylazo-8-hydroxyquinoline derivatives, M=Co(II) orCu(II) and Haa=glycine (gly), alanine (ala) or methionine (met), have been prepared. The complexes have been characterized by elemental analysis, IR and electron spectra and thermal analysis. A tetrahedral structure has been proposed for the cobalt(II) and copper(II) complexes with bidentate coordination of amino acids. The nickel(II) complexes have been assigned an octahedral structure with the amino acids acting as monodentate ligands. The thermal behaviour of the complexes has been studied before and after γ-irradiation.

Aref A. M. Aly

Papers

Voltammetric analysis of Cu (II), Cd (II) and Zn (II) complexes and their cyclic voltammetry with several cephalosporin antibiotics.

Beiträge zur Strukturchemie von Silberhalogenid-Diphosphinomethan- und verwandten Komplexen†

Mixed Ligand Complexes of 5-arylazo-8-hydroxyquinoline and α-amino Acids with Co(II), Ni(II) and Cu(II)

Synthesis and Crystal Structure of a Methylenebis(diphenylphosphane) Complex of Silver Bromide Containing a Trigonal Bipyramidal Ag3Br2 Central Unit

Synthesis of some 5-azo(4'-substituted benzene-sulphamoyl)-8-hydroxyquinolines with antidotal and antibacterial activities.