A
Ariane Mallat
Researcher at University of Paris
Publications - 81
Citations - 6751
Ariane Mallat is an academic researcher from University of Paris. The author has contributed to research in topics: Hepatic stellate cell & Receptor. The author has an hindex of 41, co-authored 76 publications receiving 6210 citations. Previous affiliations of Ariane Mallat include French Institute of Health and Medical Research & Paris 12 Val de Marne University.
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Journal ArticleDOI
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis.
Fatima Teixeira-Clerc,Boris Julien,Boris Julien,Pascale Grenard,Pascale Grenard,Jeanne Tran Van Nhieu,Jeanne Tran Van Nhieu,Vanessa Deveaux,Vanessa Deveaux,Liying Li,Liying Li,Valérie Serriere-Lanneau,Valérie Serriere-Lanneau,Catherine Ledent,Ariane Mallat,Ariane Mallat,Sophie Lotersztajn,Sophie Lotersztajn +17 more
TL;DR: The study shows that CB1 receptor antagonists hold promise for the treatment of liver fibrosis, and suggests that endocannabinoids may drive both CB2-mediated antifibrogenic effects andCB2-independent profibrogenics effects.
Journal ArticleDOI
Antifibrogenic role of the cannabinoid receptor CB2 in the liver.
Boris Julien,Boris Julien,Pascale Grenard,Pascale Grenard,Fatima Teixeira-Clerc,Fatima Teixeira-Clerc,Jeanne Tran Van Nhieu,Jeanne Tran Van Nhieu,Liying Li,Liying Li,Meliha Karsak,Andreas Zimmer,Ariane Mallat,Ariane Mallat,Sophie Lotersztajn,Sophie Lotersztajn +15 more
TL;DR: These data constitute the first demonstration that CB2 receptors are highly up-regulated in the cirrhotic liver, predominantly in hepatic fibrogenic cells and highlight the antifibrogenic role of CB2 receptor during chronic liver injury.
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M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease.
Jinghong Wan,Merieme Benkdane,Fatima Teixeira-Clerc,S. Bonnafous,Alexandre Louvet,Fouad Lafdil,Françoise Pecker,Albert Tran,Philippe Gual,Ariane Mallat,Sophie Lotersztajn,Catherine Pavoine +11 more
TL;DR: It is suggested that promoting M2‐induced M1 KC apoptosis might prove a relevant strategy to limit alcohol‐ and high fat‐induced inflammation and hepatocyte injury.
Journal ArticleDOI
HEPATIC FIBROSIS: Molecular Mechanisms and Drug Targets
TL;DR: A review highlights recent advances in the molecular mechanisms of liver fibrosis and discusses mechanistically based strategies that have recently emerged.
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Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: a randomized trial comparing 3- and 6-month periodicities.
Jean-Claude Trinchet,Cendrine Chaffaut,Valérie Bourcier,Françoise Degos,Jean Henrion,Hélène Fontaine,Dominique Roulot,Ariane Mallat,Sophie Hillaire,Paul Calès,Isabelle Ollivier,Jean-Pierre Vinel,Philippe Mathurin,Jean-Pierre Bronowicki,Valérie Vilgrain,Valérie Vilgrain,Gisèle N'Kontchou,Michel Beaugrand,Sylvie Chevret +18 more
TL;DR: US surveillance, performed every 3 months, detects more small focal lesions than US every 6 months, but does not improve detection of small HCC, probably because of limitations in recall procedures.