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Aritee R. Siafakas
Researcher at University of Sydney
Publications - 5
Citations - 423
Aritee R. Siafakas is an academic researcher from University of Sydney. The author has contributed to research in topics: Chelation & Cell cycle checkpoint. The author has an hindex of 4, co-authored 5 publications receiving 378 citations. Previous affiliations of Aritee R. Siafakas include Bosch.
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Journal ArticleDOI
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors
Yu Yu,Danuta S. Kalinowski,Zaklina Kovacevic,Aritee R. Siafakas,Patric J. Jansson,Christian Stefani,David B. Lovejoy,Philip C. Sharpe,Paul V. Bernhardt,Des R. Richardson +9 more
TL;DR: Detailed investigations of the thiosemicarbazone group of ligands have demonstrated that they are highly effective chelators that, besides RR, also target a range of other molecules including NDRG1 and top2α, all of which contribute to their anticancer effects.
Journal ArticleDOI
Cellular Iron Depletion and the Mechanisms Involved in the Iron-dependent Regulation of the Growth Arrest and DNA Damage Family of Genes
TL;DR: The effect of iron depletion on up-regulating GADD family members involved in growth control, including cell cycle arrest, apoptosis, and DNA repair, making them therapeutic targets for tumor suppression are examined.
Journal ArticleDOI
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes
Darius J.R. Lane,Dong-Hun Bae,Aritee R. Siafakas,Yohan Suryo Rahmanto,Lina Al-Akra,Patric J. Jansson,Robert A. Casero,Des R. Richardson,Des R. Richardson +8 more
TL;DR: For the first time, it is demonstrated that cellular iron levels robustly regulate 13 polyamine pathway proteins and the "reprogramming" of polyamine metabolism by iron-depletion is consistent with the down-regulation of ADI1 and MAT2α, and the up- regulation of SAT1.
Journal ArticleDOI
Thiosemicarbazones from the Old to New: Iron Chelators that Are More than Just Ribonucleotide Reductase Inhibitors
Yu Yu,Danuta S. Kalinowski,Zaklina Kovacevic,Aritee R. Siafakas,Patric J. Jansson,Christian Stefani,David B. Lovejoy,Philip C. Sharpe,Paul V. Bernhardt,Des R. Richardson +9 more
TL;DR: In this paper, the thiosemicarbazone chelators such as 3-AP and the ApT, BpT, and DpT series were investigated.
Journal ArticleDOI
Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone
Dong-Hun Bae,Darius J.R. Lane,Aritee R. Siafakas,Robert Sutak,Jasmina Paluncic,Michael L.-H. Huang,Patric J. Jansson,Yohan Suryo Rahmanto,Des R. Richardson,Des R. Richardson,Des R. Richardson +10 more
TL;DR: Poly r(C)-binding protein (PCBPs) 1 and 2 act as iron delivery chaperones to other iron-containing dioxygenases and were shown herein for the first time to be regulated by iron levels.