http://academic.oup.com/milmed/article-pdf/146/7/506/24126715/milmed-146-7-506.pdf

Goodman and Gilman's The Pharmacological Basis of Therapeutics

正しい方法がわかる臨床基本手技 : from the New England journal of medicine

An adequate supply of saliva is critical to the preservation and maintenance of oral tissue. Clinicians often do not value the many benefits of saliva until quantities are decreased. Much is written on the subject of salivary hypofunction, but little attention is paid to normal salivary flow and function. This article is a brief, up-to-date overview of the literature on the basics of normal salivary composition, flow, and function. A review of the literature was conducted using MEDLINE and Healthstar (1944 through 1999); articles were selected for inclusion on the basis of relevance and significance to the clinician.

A review of saliva: Normal composition, flow, and function

Ductal carcinoma in situ (DCIS) of the breast represents a heterogeneous group of neoplastic lesions in the breast ducts. The goal for management of DCIS is to prevent the development of invasive breast cancer. This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.

https://www.unitypoint.org/desmoines/filesimages/Cancer%20Education/Oncology%20Nursing%20Conference/2015/2014%20NCCN%20Clin%20Pract%20Guidelines%20Male%20Sex%20Dysf.pdf

Clinical practice guidelines in oncology

Platelet-rich plasma (PRP) has been utilized in surgery for 2 decades; there has been a recent interest in the use of PRP for the treatment of sports-related injuries. PRP contains growth factors and bioactive proteins that influence the healing of tendon, ligament, muscle, and bone. This article examines the basic science of PRP, and it describes the current clinical applications in sports medicine. This study reviews and evaluates the human studies that have been published in the orthopaedic surgery and sports medicine literature. The use of PRP in amateur and professional sports is reviewed, and the regulation of PRP by antidoping agencies is discussed.

Platelet-Rich Plasma From Basic Science to Clinical Applications

The causes and consequences of hyposalivation.

Rituximab therapy is a promising treatment for primary Sjogren's syndrome (pSS).1 ,2 So far, treatment studies performed in patients with pSS lacked the use of a uniform outcome measure to monitor disease activity.

Recently, the European League Against Rheumatism (EULAR) developed the EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI).3 ESSDAI was shown to be able to monitor disease activity in patient profile and open-label studies.4 ,5 To further study the utility of ESSDAI for clinical studies, we assessed the responsiveness of ESSDAI after rituximab treatment in a randomised controlled trial (RCT) of patients with pSS.6 

As the principal investigator (HB) was involved in the development of ESSDAI, the database of a single-centre, randomised, double-blind, placebo-controlled trial (see ref. 6 for details) was prospectively completed with regard to all ESSDAI domains, namely the cutaneous, respiratory, renal, articular, muscular, peripheral and central nervous system, haematological, glandular, constitutional, …

https://ard.bmj.com/content/annrheumdis/73/2/472.full.pdf

EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) is sensitive to show efficacy of rituximab treatment in a randomised controlled trial

Objectives
To identify the most discussed dental articles on the Web and to assess the association between the intensity of online attention, publication characteristics and citations.

Materials & Methods
An Altmetric Explorer search was conducted for articles published in the 91 dental journals included in 2015 InCites™ Journal Citation Report® and mentioned online at all times. The 100 articles with the highest online attention, as measured by the ‘Altmetric Attention Score’ (AAS), were screened for journal title, quartile of impact factor distribution (Q1-Q4), publication date, origin and affiliation of first author, article topic, type and access. Citation counts were harvested from Scopus.

Results
The top 100 articles presented a median AAS of 119, and were mostly discussed on news outlets, Twitter and Mendeley. Forty-one articles were published in Q1 journals, 24 in Q2 journals, 32 in Q3 journals and 3 in Q4 journals. AAS was significantly higher in articles of Q2 journals (median AAS=398, range=70-513) than of Q1. A weak reverse correlation existed between AAS and time since publication (r=-0.25, p<0.05). No correlation was detected between AAS and other publication characteristics or number of citations.

Conclusions
Increased social impact of dental articles is not significantly associated with high citation rates.

This article is protected by copyright. All rights reserved.

Measuring the social impact of dental research: An insight into the most influential articles on the Web.

Sjögren’s syndrome (SS) is an autoimmune inflammatory disorder of the exocrine glands. SS particularly affects the salivary and lacrimal glands. Patients most frequently present with dry mouth and dry eyes, which are often accompanied by nonspecific symptoms such as malaise and fatigue. Extraglandular manifestations include vasculitis, polyneuropathy, and arthritis, and these signs can present early, even at the time of diagnosis. Lymphoma develops in 5–10% of patients with SS. There is a need for early recognition and diagnosis of SS, because the health-related quality of life worsens as SS progresses. In addition, treatment using the currently available biologic agents is most effective in patients with primary SS who have high levels of disease activity and a relatively short duration of related symptoms (1). In this issue of Arthritis & Rheumatism, Cornec et al (2) propose adding salivary gland ultrasonography (SGUS) to the consensus criteria of the American– European Consensus Group (AECG) (3). As discussed by the authors, SGUS might be of value in classifying primary SS, but it is also a promising tool for earlier detection (possibly replacing the invasive salivary gland biopsy) and for monitoring disease progression. In this editorial, the term “primary” SS is used when referring to studies that were performed specifically in patients with a diagnosis of primary SS according to the AECG criteria (3). The AECG classification criteria are the most widely applied criteria for SS, but several modifications to these criteria have been suggested (2,4–6). These modifications include adding SGUS to the AECG criteria (2), limiting the classification criteria to include only objective tests (4), and replacing sialography (5) and sialoscintigraphy (6) with SGUS. Importantly, classification criteria help to define homogeneous study groups but are not intended for diagnostic purposes. Classification criteria usually have high specificity but lower sensitivity; for diagnostic purposes, sensitivity must also be high (7). In addition, diagnostic tests must be easy to perform and should not cause too much distress to the patient, especially when such tests need to be performed repeatedly, as in patients in whom the suspicion for SS is high but who have not yet fulfilled the classification criteria. SGUS might be such a test, because it is noninvasive, thus allowing repeated monitoring of the salivary glands over time. When criteria are revised, a criterion can be added to an existing criteria set or replaced by another more specific and/or sensitive criterion within that criteria set, or the whole set of criteria can be replaced by one with better properties. Both SGUS and saliva tests are very promising in the context of classification but also for diagnosis and monitoring (2,5,6,8–12). Cornec et al (and previously also Takagi et al [5] and Milic et al [6]) propose adding SGUS to the AECG criteria, because SGUS proved valuable for assessing major salivary gland involvement in primary SS and seemed to exhibit good diagnostic properties. Cornec and colleagues showed that adding SGUS to the AECG criteria increased the sensitivity of the AECG criteria for primary SS from 78% to 87% while retaining the specificity of these criteria. Scintigraphy and sialography, 2 “objective salivary gland tests” in the AECG criteria, are now considered inappropriate; it would be of great benefit if SGUS could replace these tests in the criteria set, but these studies did not address this possibility. In the study by Cornec et al, the mean SD disease duration of the included patients with primary SS was 7.1 7.5 years, which can be considered a limitation of their study. Our group (10) showed that in the early stages of SS, the function of the parotid gland H. Bootsma, MD, PhD, F. K. L. Spijkervet, DMD, PhD, F. G. M. Kroese, PhD, A. Vissink, MD, DMD, PhD: University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. Address correspondence to H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. E-mail: h.bootsma@umcg.nl. Submitted for publication May 21, 2012; accepted in revised form September 4, 2012.

Arjan Vissink

Papers

The causes and consequences of hyposalivation.

EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) is sensitive to show efficacy of rituximab treatment in a randomised controlled trial

Measuring the social impact of dental research: An insight into the most influential articles on the Web.

Toward new classification criteria for Sjögren's syndrome?

FcRL4(+) B-cells in salivary glands of primary Sjogren's syndrome patients