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Arjun Kalvala
Researcher at Ohio State University
Publications - 11
Citations - 157
Arjun Kalvala is an academic researcher from Ohio State University. The author has contributed to research in topics: Mitochondrial ROS & Venetoclax. The author has an hindex of 7, co-authored 11 publications receiving 114 citations. Previous affiliations of Arjun Kalvala include International Centre for Genetic Engineering and Biotechnology & City of Hope National Medical Center.
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Journal ArticleDOI
The Bcl-2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML.
Le Xuan Truong Nguyen,Estelle Troadec,Arjun Kalvala,Bijender Kumar,Dinh Hoa Hoang,Domenico Viola,Bin Zhang,Dang Quan Nguyen,Ibrahim Aldoss,Lucy Ghoda,Elizabeth Budde,Flavia Pichiorri,Steven D. Rosen,Steven D. Rosen,Stephen J. Forman,Stephen J. Forman,Guido Marcucci,Guido Marcucci,Vinod Pullarkat,Vinod Pullarkat +19 more
TL;DR: An undiscovered mechanism underlying synergistic effect of decitabine and venetoclax in AML cells is demonstrated, elucidating for impressive results in antileukemic activity against AML in preclinical and early clinical studies by combined treatment of these drugs.
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Fanconi Anemia Repair Pathway Dysfunction, a Potential Therapeutic Target in Lung Cancer
Wenrui Duan,Li Gao,Brittany Aguila,Arjun Kalvala,Gregory A. Otterson,Miguel A. Villalona-Calero +5 more
TL;DR: A subset of lung cancer patients are likely to be more susceptible to DNA cross-link based therapy, or to treatments in which additional repair mechanisms are targeted, given that FA pathway plays essential roles in response to DNA damage.
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Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS
Arjun Kalvala,Pierre Wallet,Lu Yang,Chongkai Wang,Haiqing Li,Arin Nam,Anusha Nathan,Isa Mambetsariev,Valeriy Poroyko,Hanlin Gao,Peiguo Chu,Martin Sattler,Andrea Bild,Edwin R. Manuel,Peter P. Lee,Mohit Kumar Jolly,Prakash Kulkarni,Ravi Salgia +17 more
TL;DR: It is demonstrated that CD4+ T cells when incubated with tumor-derived exosomes from mutant (MT) KRAS non-small-cell lung cancer (NSCLC) cells, patient sera, or a mouse xenograft model, induce phenotypic conversion to FOXP3+ Treg-like cells that are immune-suppressive.
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Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia.
Bijender Kumar,Arjun Kalvala,Su Chu,Steven D. Rosen,Stephen J. Forman,Guido Marcucci,Ching-Cheng Chen,Vinod Pullarkat +7 more
TL;DR: The results demonstrate the potent preclinical antileukemic activity of ARTS as well as its potential for a rapid transition to a clinical trial either alone or in combination with conventional chemotherapy or BCL-2 inhibitor, for treatment of AML.
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Enhancement of gene targeting in human cells by intranuclear permeation of the Saccharomyces cerevisiae Rad52 protein
Arjun Kalvala,Giuseppe Rainaldi,Cristina Di Primio,Vania Liverani,Arturo Falaschi,Alvaro Galli +5 more
TL;DR: The yRad52tat11 fusion protein could be instrumental to increase GT in human cells and a ‘protein delivery approach’ offers a new tool for developing novel strategies for genome modification and gene therapy applications.