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Bin Zhang
Researcher at City of Hope National Medical Center
Publications - 74
Citations - 4843
Bin Zhang is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Leukemia & Stem cell. The author has an hindex of 27, co-authored 65 publications receiving 3370 citations. Previous affiliations of Bin Zhang include Beckman Research Institute & University of Southern California.
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Journal ArticleDOI
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Rui Su,Lei Dong,Chenying Li,Sigrid Nachtergaele,Mark Wunderlich,Ying Qing,Xiaolan Deng,Yungui Wang,Yungui Wang,Xiaocheng Weng,Chao Hu,Chao Hu,Mengxia Yu,Jennifer R. Skibbe,Qing Dai,Dongling Zou,Tong Wu,Kangkang Yu,Hengyou Weng,Huilin Huang,Kyle Ferchen,Xi Qin,Bin Zhang,Jun Qi,Atsuo T. Sasaki,David R. Plas,James E. Bradner,Minjie Wei,Guido Marcucci,Xi Jiang,James C. Mulloy,Jie Jin,Chuan He,Jianjun Chen,Jianjun Chen +34 more
TL;DR: While R-2HG accumulated in IDH1/2 mutant cancers contributes to cancer initiation, this work demonstrates anti-tumor effects of 2HG in inhibiting proliferation/survival of FTO-high cancer cells via targeting FTO/m6A/MYC/CEBPA signaling.
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METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification
Hengyou Weng,Huilin Huang,Huizhe Wu,Xi Qin,Boxuan Simen Zhao,Lei Dong,Hailing Shi,Jennifer R. Skibbe,Chao Shen,Chao Hu,Chao Hu,Yue Sheng,Yungui Wang,Yungui Wang,Mark Wunderlich,Bin Zhang,Louis C. Dore,Rui Su,Xiaolan Deng,Xiaolan Deng,Kyle Ferchen,Chenying Li,Chenying Li,Miao Sun,Zhike Lu,Xi Jiang,Guido Marcucci,James C. Mulloy,Jian-Hua Yang,Zhijian Qian,Minjie Wei,Chuan He,Jianjun Chen +32 more
TL;DR: The results reveal the SPI1-METTL14-MYB/MYC signaling axis in myelopoiesis and leukemogenesis and highlight the critical roles of METTL14 and m6A modification in normal and malignant hematopoiedis.
Journal ArticleDOI
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
Ashley Hamilton,G. Vignir Helgason,Mirle Schemionek,Bin Zhang,Svetlana Myssina,Elaine K. Allan,Franck E. Nicolini,Carsten Müller-Tidow,Ravi Bhatia,Valerie G. Brunton,Steffen Koschmieder,Tessa L. Holyoake +11 more
TL;DR: It is suggested that CML stem cell survival is Bcr-Abl kinase independent and curative approaches in CML must focus on kinase-independent mechanisms of resistance.
Journal ArticleDOI
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Rui Su,Lei Dong,Yangchan Li,Min Gao,Li Han,Mark Wunderlich,Xiaolan Deng,Hongzhi Li,Yue Huang,Lei Gao,Chenying Li,Zhicong Zhao,Sean Robinson,Brandon Tan,Ying Qing,Xi Qin,Emily Prince,Jun Xie,Hanjun Qin,Wei Li,Chao Shen,Jie Sun,Prakash Kulkarni,Hengyou Weng,Huilin Huang,Zhenhua Chen,Bin Zhang,Xiwei Wu,Mark Olsen,Markus Müschen,Guido Marcucci,Guido Marcucci,Ravi Salgia,Ling Li,Ling Li,Amir T. Fathi,Zejuan Li,James C. Mulloy,Minjie Wei,David Horne,Jianjun Chen,Jianjun Chen +41 more
TL;DR: It is shown that genetic depletion and pharmacological inhibition of FTO dramatically attenuate leukemia stem/initiating cell self-renewal and reprogram immune response by suppressing expression of immune checkpoint genes, especially LILRB4.
Journal ArticleDOI
Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia
Bin Zhang,Yin Wei Ho,Qin Huang,Takahiro Maeda,Allen Lin,Sung-Uk Lee,Alan Hair,Tessa L. Holyoake,Claudia S. Huettner,Ravi Bhatia +9 more
TL;DR: CML LTHSC demonstrated reduced homing and retention in the bone marrow, related to decreased CXCL12 expression in CML BM, resulting from increased G-CSF production by leukemia cells.