Showing papers by "Arleen D. Auerbach published in 1999"
TL;DR: It is concluded that another tumor suppressor must be targeted by LOH in sporadic breast cancer, and the PISSLRE gene is screened by analyzing each exon by single-strand conformational polymorphism.
43 citations
TL;DR: Fanconi anaemia A gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer, but another tumour suppressor gene in this chromosomal region remains to be identified.
Abstract: The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified.
20 citations
TL;DR: A Unique Effect in Fanconi Anemia: Apparent Decrease of Only Type I Collagen Formation by Increased Amounts of Endogenous Growth Hormone is apparent.
Abstract: A Unique Effect in Fanconi Anemia: Apparent Decrease of Only Type I Collagen Formation by Increased Amounts of Endogenous Growth Hormone
1 citations