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Arne Holmgren
Researcher at Karolinska Institutet
Publications - 411
Citations - 47758
Arne Holmgren is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Thioredoxin & Thioredoxin reductase. The author has an hindex of 113, co-authored 407 publications receiving 44645 citations. Previous affiliations of Arne Holmgren include Harvard University & Uppsala University.
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Journal ArticleDOI
Physiological functions of thioredoxin and thioredoxin reductase.
Elias S.J. Arnér,Arne Holmgren +1 more
TL;DR: All mammalian thioredoxin reduct enzyme isozymes are homologous to glutathione reductase and contain a conserved C-terminal elongation with a cysteine-selenocysteine sequence forming a redox-active selenenylsulfide/selenolthiol active site and are inhibited by goldthioglucose and other clinically used drugs.
Journal ArticleDOI
The thioredoxin antioxidant system.
Jun Lu,Arne Holmgren +1 more
TL;DR: The absence of a GSH-Grx system in some pathogenic bacteria such as Helicobacter pylori, Mycobacterium tuberculosis, and Staphylococcus aureus makes the bacterial Trx system essential for survival under oxidative stress, and provides an opportunity to kill these bacteria by targeting the TrxR-Trx system.
Journal ArticleDOI
From selenium to selenoproteins: Synthesis, identity, and their role in human health
TL;DR: The function of most selenoproteins is currently unknown; however, thioredoxin reductases, glutathione peroxidases and thyroid hormone deiodinases are well characterised selenobroteins involved in redox regulation of intracellular signalling, redox homeostasis and thyroid hormones metabolism.
Book ChapterDOI
Thioredoxin and thioredoxin reductase.
Arne Holmgren,Mikael Björnstedt +1 more
TL;DR: This chapter summarizes current methods to determine Trx and thioredoxin reductase (TR), which are likely to be involved in multiple signaling systems for redox control of cellular processes.