Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)

CHAPTER 24 – Evolution of Protein Molecules

So far in this course we have dealt entirely with the evolution of characters that are controlled by simple Mendelian inheritance at a single locus. There are notes on the course website about gametic disequilibrium and how allele frequencies change at two loci simultaneously, but we didn’t discuss them. In every example we’ve considered we’ve imagined that we could understand something about evolution by examining the evolution of a single gene. That’s the domain of classical population genetics. For the next few weeks we’re going to be exploring a field that’s actually older than classical population genetics, although the approach we’ll be taking to it involves the use of population genetic machinery. If you know a little about the history of evolutionary biology, you may know that after the rediscovery of Mendel’s work in 1900 there was a heated debate between the “biometricians” (e.g., Galton and Pearson) and the “Mendelians” (e.g., de Vries, Correns, Bateson, and Morgan). Biometricians asserted that the really important variation in evolution didn’t follow Mendelian rules. Height, weight, skin color, and similar traits seemed to

Human biochemical genetics

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

Appendix I: List of Statistical Fact Sheets. URL: http://www.americanheart.org/presenter.jhtml?identifier=2007

We wish to thank Drs Brian Eigel and Michael Wolz for their valuable comments and contributions. We would like to acknowledge Tim Anderson and Tom Schneider for their editorial contributions and Karen Modesitt for her administrative assistance.

Disclosures 



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# Summary {#article-title-2}

Each year, the American Heart Association, in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a valuable resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best national data available on disease …

Heart Disease and Stroke Statistics—2010 Update A Report From the American Heart Association

Medical genetics in the Pacific area.

Quantitative aspects of erythropoiesis in man.

The living conditions of human populations have altered in recent generations and are still changing at an increasing rate in most countries. From the viewpoint of human health and life expectancy, the most spectacular changes have occurred due to progress in hygiene and medicine. These developments must influence human fertility and mortality and, hence, the genetic composition of future generations. Moreover, improving knowledge in human genetics has led to practical applications at an increasing rate — especially in genetic counseling and genetic screening. These approaches are promoted not primarily to improve future generations genetically but to avoid unnecessary hardships for present-day families. However, the widespread utilization of genetic counseling and genetic screening will also influence the genetic composition of future generations. More recently, molecular biology has provided increasingly efficient techniques for genetic diagnosis and, probably, therapy.

Practical Applications of Human Genetics and the Biological Future of Mankind

Bookman et al . write to correct the impression given in the Commentary by Kohane and Taylor that the recommendations of the National Heart, Lung, and Blood Institute (NHLBI) Working Group “Reporting Genetic Results in Research Studies” included advice to return genetic information to research subjects only in cases where there is a proven or preventative intervention for the identified disorder. In fact, the report does recommend that genetic information be returned to subjects when there is an intervention available, but it does not recommend against giving this kind of information to subjects if there is no available intervention.

https://stm.sciencemag.org/content/scitransmed/3/70/70le1.full.pdf

Comment on “Multidimensional Results Reporting to Participants in Genomic Studies: Getting It Right”

/pdf/introduction-the-new-genetics-and-health-care-5bslw7r9ej.pdf

Arno G. Motulsky

Papers

Medical genetics in the Pacific area.

Quantitative aspects of erythropoiesis in man.

Practical Applications of Human Genetics and the Biological Future of Mankind

Comment on “Multidimensional Results Reporting to Participants in Genomic Studies: Getting It Right”

Introduction: The New Genetics and Health Care