Arno G. Motulsky

TL;DR: The ratio of paraoxonase over that of chlorpyrifos oxonase provided an excellent method for genetic typing of the paraox onase polymorphism, as did the substitution of phenylacetate for chlorparyifos as the substrate.

TL;DR: A Working Group on Reporting Genetic Results in Research Studies concluded that genetic test results should be reported to study participants when the associated risk for the disease is significant; the disease has important health implications such as premature death or substantial morbidity or has significant reproductive implications; and proven therapeutic or preventive interventions are available.

TL;DR: It is recognized that the sickle-cell trait and the hemoglobin C trait are common among blacks in the United States and will not be discovered in many routine screening programs since detection requires special technics.

TL;DR: A very high degree of protection, particularly toward brain and diaphragm cholinesterase, was provided by paraoxonase pretreatment in animals challenged with chlorpyrifos-oxon by all routes.

TL;DR: The consensus of the CWG and NSGC reviewers is that beyond a thorough medical family history with follow-up of significant findings, no additional preconception screening is recommended for consanguineous couples.