Arthur L. Brody

TL;DR: A model is presented which describes how frontal-subcortical brain circuitry may mediate OCD symptomatology, and a hypothesis for how successful treatments may ameliorate symptoms, via their effects on circuit activity is suggested.

TL;DR: In this paper, the authors examined baseline regional metabolic abnormalities and metabolic changes from pretreatment to post-treatment in subjects with major depressive disorder (MDD) and performed a preliminary comparison of regional changes with two distinct forms of treatment (paroxetine and interpersonal psychotherapy) and found that subjects with MDD had metabolic changes in the direction of normalization in these regions.

TL;DR: Subjects with MDD had regional brain metabolic abnormalities at baseline that tended to normalize with treatment, and regional metabolic changes appeared similar with the 2 forms of treatment.

TL;DR: Brain regions associated with arousal, compulsive repetitive behaviors, sensory integration, and episodic memory are activated during exposure to cigarette-related cues and cigarette craving, similar to findings with other addictive substances.

TL;DR: Smokers and nonsmokers differed in regional gray matter in brain areas previously linked with nicotine dependence, which might reflect effects of chronic smoking, predisposing traits that lead to smoking, or some combination of these factors.