Sanjaya Saxena

TL;DR: A model is presented which describes how frontal-subcortical brain circuitry may mediate OCD symptomatology, and a hypothesis for how successful treatments may ameliorate symptoms, via their effects on circuit activity is suggested.

TL;DR: This work has shown that interventions that directly alter the indirect-direct pathway balance within frontal-subcortical circuits will allow for direct testing of the pathophysiologic hypotheses presented here.

TL;DR: The results indicate that the combination of cerebral metabolic rates and genetic risk factors provides a means for preclinical AD detection that will assist in response monitoring during experimental treatments.

TL;DR: In this paper, the authors examined baseline regional metabolic abnormalities and metabolic changes from pretreatment to post-treatment in subjects with major depressive disorder (MDD) and performed a preliminary comparison of regional changes with two distinct forms of treatment (paroxetine and interpersonal psychotherapy) and found that subjects with MDD had metabolic changes in the direction of normalization in these regions.

TL;DR: Subjects with MDD had regional brain metabolic abnormalities at baseline that tended to normalize with treatment, and regional metabolic changes appeared similar with the 2 forms of treatment.