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Arun V. Holden
Researcher at University of Leeds
Publications - 242
Citations - 5446
Arun V. Holden is an academic researcher from University of Leeds. The author has contributed to research in topics: Sinoatrial node & Excitable medium. The author has an hindex of 38, co-authored 240 publications receiving 5186 citations. Previous affiliations of Arun V. Holden include Anhui Normal University & University of Cambridge.
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Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node
TL;DR: Simulated action potentials are consistent with those recorded experimentally and have a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase 1 repolarization, greater amplitude, shorter duration, and more negative maximum diastolic potential than the model-generated central action potential.
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Heterogeneous three-dimensional anatomical and electrophysiological model of human atria
TL;DR: A biophysical detailed and anatomically accurate computer model of human atria that incorporates both structural and electrophysiological heterogeneities is constructed and revealed that bundles form dominant pathways for atrial conduction.
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Tension of organizing filaments of scroll waves
TL;DR: In this article, the authors consider the asymptotic theory for organizing filaments of three-dimensional scroll waves and show that some of the coefficients of the evolution equation are always zero.
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3D virtual human atria: A computational platform for studying clinical atrial fibrillation
Oleg Aslanidi,Michael A. Colman,Jonathan Stott,Halina Dobrzynski,Mark R. Boyett,Arun V. Holden,Henggui Zhang,Henggui Zhang +7 more
TL;DR: A state-of-the-art computational platform has been developed, which can be used for studying multi-scale electrical phenomena during atrial conduction and AF arrhythmogenesis, and can be directly compared with electrophysiological and endocardial mapping data, as well as clinical ECG recordings.
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Regional localisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure.
TL;DR: Evidence points to significant inter-individual structural variability in the canine, leading to the concept of a continuum (or distribution) of cardiac structures, which partly explains the ongoing debate on myocardial architecture.