Arunasiri Iddamalgoda

TL;DR: The findings strongly implicate that tryptase either alone or in conjunction with activation of MMPs, can participate in ECM damage and the possible destruction of BM leading to photoaging.

TL;DR: It is found that either parthenolide or magnolol could effectively inhibit the gene expression mediated by NF-κB and the production of bFGF and MMP-1 from cells overexpressing p65, a major subunit of NF-γB.

TL;DR: The present study demonstrates the production of ACTH(1–8) from POMC by tryptase, which is a novel peptide-processing mechanism in the extracellular compartment of the skin.

TL;DR: Findings indicate a new target for vitiligo treatment, focusing on the novel role of IFN-γ and IL-17 in downregulating keratinocyte-GPNMB, which is involved in multiple cellular functions including cell adhesion, stress protection and stem cell maintenance.

TL;DR: Investigation of the anti-inflammatory effects of an extract from Cynara scolymus L. and its pharmacologically effective compound cynaropicrin on human gingival fibroblasts stimulated by LPS and the potential anti-osteoclastogenic effects on RAW264.7 cells suggested that cynaropyrin may be useful for preventing periodontal diseases.