N
Norihisa Watanabe
Researcher at Nihon University
Publications - 9
Citations - 225
Norihisa Watanabe is an academic researcher from Nihon University. The author has contributed to research in topics: Proinflammatory cytokine & Cytokine. The author has an hindex of 5, co-authored 8 publications receiving 89 citations.
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Journal ArticleDOI
Aspiration of periodontopathic bacteria due to poor oral hygiene potentially contributes to the aggravation of COVID-19.
Yuwa Takahashi,Norihisa Watanabe,Noriaki Kamio,Ryutaro Kobayashi,Toshimitsu Iinuma,Kenichi Imai +5 more
TL;DR: It can be hypothesized that periodontopathic bacteria are involved in the COVID-19 aggravation and therefore, the management of good oral hygiene potentially contributes to its prevention.
Journal ArticleDOI
Expression of the SARS-CoV-2 Receptor ACE2 and Proinflammatory Cytokines Induced by the Periodontopathic Bacterium Fusobacterium nucleatum in Human Respiratory Epithelial Cells.
Yuwa Takahashi,Norihisa Watanabe,Noriaki Kamio,Sho Yokoe,Ryuta Suzuki,Shuichi Sato,Toshimitsu Iinuma,Kenichi Imai +7 more
TL;DR: The results suggest that when patients with mild COVID-19 frequently aspirate periodontopathic bacteria, SARS-CoV-2 infection is promoted, and inflammation in the lower respiratory tract may become severe in the presence of viral pneumonia.
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The Periodontopathic Bacterium Fusobacterium nucleatum Induced Proinflammatory Cytokine Production by Human Respiratory Epithelial Cell Lines and in the Lower Respiratory Organs in Mice
Mayumi Hayata,Norihisa Watanabe,Muneaki Tamura,Noriaki Kamio,Hajime Tanaka,Keiko Nodomi,Chihiro Miya,Enri Nakayama,Koichiro Ueda,Yorimasa Ogata,Kenichi Imai +10 more
TL;DR: Exposure to increased number of F. nucleatum potentially induces proinflammatory cytokine production by human bronchial and pharyngeal epithelial cells, which may trigger exacerbation of COPD.
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Butyric Acid in Saliva of Chronic Periodontitis Patients Induces Transcription of the EBV Lytic Switch Activator BZLF1: A Pilot Study.
Ryo Koike,Keiko Nodomi,Norihisa Watanabe,Yorimasa Ogata,Osamu Takeichi,Masami Takei,Tadayoshi Kaneko,Morio Tonogi,Ai Kotani,Kenichi Imai +9 more
TL;DR: BA in saliva may play a role in EBV reactivation and hence contribute to EBV-related disease progression in CP patients, as expected, CP patients' saliva induced AcH3.
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Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells
Mayumi Hayata,Norihisa Watanabe,Noriaki Kamio,Muneaki Tamura,Keiko Nodomi,Kiyotaka Tanaka,Arunasiri Iddamalgoda,Hiromasa Tsuda,Yorimasa Ogata,Shuichi Sato,Kouichiro Ueda,Kenichi Imai +11 more
TL;DR: Investigation of the anti-inflammatory effects of an extract from Cynara scolymus L. and its pharmacologically effective compound cynaropicrin on human gingival fibroblasts stimulated by LPS and the potential anti-osteoclastogenic effects on RAW264.7 cells suggested that cynaropyrin may be useful for preventing periodontal diseases.