Arya Mani

TL;DR: A single gene defect in Wnt signaling is linked to CAD and multiple cardiovascular risk factors through genetic linkage to a short segment of chromosome 12p, in which a missense mutation in LRP6 encodes a co-receptor in the Wnt pathway.

TL;DR: The physiological role of the LDLR family of proteins is reviewed and its involvement in pathogenesis of hyperlipidemia and atherosclerosis is described.

TL;DR: Functional characterization of the disease gene revealed that nonmutant protein encoded by DYRK1B inhibits the SHH (sonic hedgehog) and Wnt signaling pathways and consequently enhances adipogenesis and glucose homeostasis and associate its altered function with an inherited form of the metabolic syndrome.

TL;DR: The genetic studies of obesity and metabolic syndrome have identified novel molecules acting on the hunger and satiety peptidergic signaling of the gut-hypothalamus axis or the melanocortin system of the brain and are promising targets for future drug development.

TL;DR: This review will discuss the shared genetic and molecular factors central to CVD and cancer and how the strategies commonly used for the prevention of atherosclerotic vascular disease can be applied to cancer prevention.