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Asad Ashraf
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 5
Citations - 627
Asad Ashraf is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Germline & Germline mutation. The author has an hindex of 5, co-authored 5 publications receiving 505 citations.
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Journal ArticleDOI
Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA
Kasmintan A. Schrader,Kasmintan A. Schrader,Kasmintan A. Schrader,Donavan T. Cheng,Vijai Joseph,Vijai Joseph,Meera Prasad,Michael Walsh,Ahmet Zehir,Ai Ni,Tinu Thomas,Ryma Benayed,Asad Ashraf,Annie Lincoln,Maria E. Arcila,Zsofia K. Stadler,David B. Solit,David M. Hyman,Liying Zhang,David S. Klimstra,Marc Ladanyi,Kenneth Offit,Michael F. Berger,Mark E. Robson,Mark E. Robson +24 more
TL;DR: Germline variants are common in individuals undergoing tumor-normal sequencing and may reveal otherwise unsuspected syndromic associations in patients with advanced cancer diagnoses.
Journal ArticleDOI
Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels
Zsofia K. Stadler,Francesca Battaglin,Sumit Middha,Jaclyn F. Hechtman,Christina Tran,Andrea Cercek,Rona Yaeger,Neil H. Segal,Anna M. Varghese,Diane Reidy-Lagunes,Nancy E. Kemeny,Erin E. Salo-Mullen,Asad Ashraf,Martin R. Weiser,Julio Garcia-Aguilar,Mark E. Robson,Kenneth Offit,Maria E. Arcila,Michael F. Berger,Jinru Shia,David B. Solit,Leonard B. Saltz +21 more
TL;DR: A cutoff for mutational load can be identified via multigene NGS tumor profiling, which provides a highly accurate means of screening for MMR-D in the same assay that is used for tumor genotyping.
Journal ArticleDOI
Identification of germline genetic mutations in patients with pancreatic cancer
Erin E. Salo-Mullen,Eileen M. O'Reilly,David P. Kelsen,Asad Ashraf,Maeve A. Lowery,Kenneth H. Yu,Diane Lauren Reidy,Andrew S. Epstein,Anne Lincoln,Amethyst Saldia,Lauren Jacobs,Rohini Rau-Murthy,Liying Zhang,Robert C. Kurtz,Leonard B. Saltz,Kenneth Offit,Mark E. Robson,Zsofia K. Stadler +17 more
TL;DR: The authors sought to determine mutation prevalence and characteristics that are predictive of an inherited predisposition for PAC.
Journal ArticleDOI
An analysis of the association between prostate cancer risk loci, PSA levels, disease aggressiveness and disease-specific mortality
John F. Sullivan,Ryan P. Kopp,Kelly L. Stratton,Christopher Manschreck,Marina Corines,Rohini Rau-Murthy,James E. Hayes,A Lincon,Asad Ashraf,Tinu Thomas,Kasmintan A. Schrader,David J. Gallagher,Robert J. Hamilton,Howard I. Scher,Hans Lilja,Peter T. Scardino,James A. Eastham,Kenneth Offit,Joseph Vijai,Robert J. Klein +19 more
TL;DR: Assessment of the frequency of known PCa susceptibility alleles within a single institution ascertainment confirmed that rs17632542 in KLK3 is associated with PSA at diagnosis, providing further evidence thatknown PCa risk SNPs do not predict likelihood of disease progression.
Journal ArticleDOI
Tumor relevant germline findings in targeted tumor sequencing using matched normal DNA of 1,570 unselected cases.
Kasmintan A. Schrader,Donavan T. Cheng,Joseph Vijai,Meera Prasad,Michael Walsh,Ahmet Zehir,Tinu Thomas,Ryma Benayed,Zsofia K. Stadler,Asad Ashraf,Maria E. Arcila,David B. Solit,David M. Hyman,Liying Zhang,David S. Klimstra,Marc Ladanyi,Kenneth Offit,Michael F. Berger,Mark E. Robson +18 more
TL;DR: The burden of TR-PPGV identified in tumor-normal massively parallel sequencing, and known genotype-phenotype correlations in cases harboring sequence PPGV in cancer-related genes of accepted clinical utility, is estimated.