K
Kenneth Offit
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 644
Citations - 53769
Kenneth Offit is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 122, co-authored 576 publications receiving 46548 citations. Previous affiliations of Kenneth Offit include University of Toronto & Georgetown University.
Papers
More filters
Journal ArticleDOI
Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.
Noah D. Kauff,Jaya M. Satagopan,Mark E. Robson,Lauren Scheuer,Martee L. Hensley,Clifford A. Hudis,Nathan A. Ellis,Jeff Boyd,Patrick I. Borgen,Richard R. Barakat,Larry Norton,Mercedes Castiel,Khedoudja Nafa,Kenneth Offit +13 more
TL;DR: Sporting risk-reducing salpingo-oophorectomy in carriers of BRCA mutations can decrease the risk of breast cancer and BRCa-related gynecologic cancer.
Journal ArticleDOI
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer
Colin C. Pritchard,Joaquin Mateo,Michael Walsh,Navonil De Sarkar,Wassim Abida,Himisha Beltran,Andrea Garofalo,Roman Gulati,Suzanne Carreira,Rosalind A. Eeles,Olivier Elemento,Mark A. Rubin,Dan R. Robinson,Robert J. Lonigro,Maha Hussain,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Jake Vinson,Julie Filipenko,Levi A. Garraway,Mary-Ellen Taplin,Saud H. AlDubayan,G. Celine Han,Mallory Beightol,Colm Morrissey,Belinda Nghiem,Heather H. Cheng,Bruce Montgomery,Tom Walsh,Silvia Casadei,Silvia Casadei,Michael F. Berger,Liying Zhang,Ahmet Zehir,Joseph Vijai,Howard I. Scher,Charles L. Sawyers,Nikolaus Schultz,Philip W. Kantoff,David B. Solit,Mark E. Robson,Eliezer M. Van Allen,Kenneth Offit,Johann S. de Bono,Peter S. Nelson,Peter S. Nelson +45 more
TL;DR: The frequency of germline mutations in DNA-repair genes among men with metastatic prostate cancer significantly exceeded the prevalence of 4.6% among 499 men with localized prostate cancer and 2.7% in the Exome Aggregation Consortium, which includes 53,105 persons without a known cancer diagnosis.
Journal ArticleDOI
Recommendations for follow-up care of individuals with an inherited predisposition to Cancer. II. BRCA1 and BRCA2
Wylie Burke,Mary B. Daly,Judy Garber,Jeffrey R. Botkin,Mary Jo Ellis Kahn,Patrick M. Lynch,Anne McTiernan,Kenneth Offit,Jeffrey M. Perlman,Gloria M. Petersen,Elizabeth J. Thomson,Claudette Varricchio +11 more
TL;DR: It is recommended that individuals considering genetic testing be counseled regarding the unknown efficacy of measures to reduce risk and that care for individuals with cancer-predisposing mutations be provided whenever possible within the context of research protocols designed to evaluate clinical outcomes.
Journal ArticleDOI
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Sean V. Tavtigian,Jacques Simard,Johanna M. Rommens,Fergus J. Couch,Donna M Shattuck-Eidens,Susan L. Neuhausen,Sofia D. Merajver,Steinunn Thorlacius,Kenneth Offit,Dominique Stoppa-Lyonnet,Carole Bélanger,Russell Bell,Simin Berry,Robert Bogden,Qian Chen,Thaylon Davis,Martine Dumont,Cheryl Frye,T. Hattier,Srikanth Jammulapati,Teresa Janecki,Ping Jiang,Robert Kehrer,J.-F. Leblanc,J.T. Mitchell,Jodi Mcarthur-Morrison,K. Nguyen,Yi Peng,Chantal Samson,Marianne Schroeder,S.C. Snyder,Linda Steele,M. Stringfellow,C. Stroup,Bradley D. Swedlund,J. Swense,David H. F. Teng,Alun Thomas,T.D. Tran,Martine Tranchant,Jane Weaver-Feldhaus,Alexander K. C. Wong,Hiroaki Shizuya,Jorunn E. Eyfjord,Lisa A. Cannon-Albright,Fernand Labrie,Mark H. Skolnick,Mark H. Skolnick,Barbara L. Weber,Alexander Kamb,David E. Goldgar,David E. Goldgar +51 more
TL;DR: The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported.
Journal ArticleDOI
Recommendations for Follow-up Care of Individuals With an Inherited Predisposition to Cancer: I. Hereditary Nonpolyposis Colon Cancer
Wylie Burke,Gloria M. Petersen,Patrick M. Lynch,Jeffrey R. Botkin,Mary B. Daly,Judy Garber,Mary Jo Ellis Kahn,Anne McTiernan,Kenneth Offit,Elizabeth J. Thomson,Claudette Varricchio +10 more
TL;DR: It is recommended that individuals considering genetic testing be counseled regarding the unknown efficacy of measures to reduce risk and that care for individuals with cancer-predisposing mutations be provided whenever possible within the context of research protocols designed to evaluate clinical outcomes.