A
Asaf Vivante
Researcher at Boston Children's Hospital
Publications - 66
Citations - 2906
Asaf Vivante is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Exome sequencing. The author has an hindex of 23, co-authored 48 publications receiving 1969 citations. Previous affiliations of Asaf Vivante include Sheba Medical Center & Tel Aviv University.
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Journal ArticleDOI
Exploring the genetic basis of early-onset chronic kidney disease
TL;DR: The implications of next-generation sequencing in clinical genetic diagnostics and the discovery of novel genes in early-onset CKD are discussed and the resulting opportunities for deciphering disease mechanisms and the therapeutic implications.
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Mutations in 12 known dominant disease-causing genes clarify many congenital anomalies of the kidney and urinary tract
Daw Yang Hwang,Daw Yang Hwang,Gabriel C. Dworschak,Gabriel C. Dworschak,Stefan Kohl,Pawaree Saisawat,Asaf Vivante,Alina C. Hilger,Heiko Reutter,Heiko Reutter,Neveen A. Soliman,Radovan Bogdanovic,Elijah O. Kehinde,Velibor Tasic,Friedhelm Hildebrandt,Friedhelm Hildebrandt +15 more
TL;DR: In a large cohort over 6% of families with isolated CAKUT are caused by a mutation in 12 of the 17 known dominantCAKUT-causing genes, which represents one of the most in-depth diagnostic studies of monogenic causes of isolated CAkUT in children.
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Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia
Karl P. Schlingmann,Justyna Ruminska,Martin Kaufmann,Ismail Dursun,Monica Patti,Birgitta Kranz,Ewa Pronicka,Elżbieta Ciara,Teoman Akcay,Derya Bulus,Elisabeth A.M. Cornelissen,Aneta Gawlik,Przemysław Sikora,Ludwig Patzer,Matthias Galiano,Veselin Boyadzhiev,Miroslav Dumić,Asaf Vivante,Robert Kleta,Benjamin Dekel,Elena Levtchenko,René J. M. Bindels,Stephan Rust,Ian C. Forster,Nati Hernando,Glenville Jones,Carsten A. Wagner,Martin Konrad +27 more
TL;DR: Human and mice data together demonstrate that primary renal phosphate wasting caused by defective NaPi-IIa function induces inappropriate production of 1,25-(OH)2D3 with subsequent symptomatic hypercalcemia.
Journal ArticleDOI
Persistent Asymptomatic Isolated Microscopic Hematuria in Israeli Adolescents and Young Adults and Risk for End-Stage Renal Disease
Asaf Vivante,Arnon Afek,Yael Frenkel-Nir,Dorit Tzur,Alon Farfel,Eliezer Golan,Yoram Chaiter,Tamy Shohat,Karl Skorecki,Ronit Calderon-Margalit +9 more
TL;DR: The presence of persistent asymptomatic isolated microscopic hematuria in persons aged 16 through 25 years was associated with significantly increased risk of treated ESRD for a period of 22 years, although the incidence and absolute risk remain quite low.
Journal ArticleDOI
Single-gene causes of congenital anomalies of the kidney and urinary tract (CAKUT) in humans
Asaf Vivante,Asaf Vivante,Stefan Kohl,Daw-Yang Hwang,Gabriel C. Dworschak,Friedhelm Hildebrandt,Friedhelm Hildebrandt +6 more
TL;DR: This work focuses here on single-gene causes of CAKUT and their developmental origin, and more than 20 monogenicCAKUT-causing genes have been identified.