R
René J. M. Bindels
Researcher at Radboud University Nijmegen
Publications - 309
Citations - 25155
René J. M. Bindels is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Reabsorption & Kidney. The author has an hindex of 82, co-authored 304 publications receiving 22821 citations. Previous affiliations of René J. M. Bindels include Radboud University Nijmegen Medical Centre & Catholic University of Leuven.
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Journal ArticleDOI
Magnesium in Man: Implications for Health and Disease
TL;DR: An extensive and comprehensive overview of Mg(2+) research over the last few decades is provided, focusing on the regulation of M g(2+) homeostasis in the intestine, kidney, and bone and disturbances which may result in hypomagnesemia.
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Calcium Absorption Across Epithelia
TL;DR: The characteristics of epithelial Ca(2+) transport in general are described and in particular the distinctive features and the physiological relevance of the new epithelialCa(2+)-transporting channels accumulating in a comprehensive model for epithelia absorption are highlighted.
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A Unified Nomenclature for the Superfamily of TRP Cation Channels
Craig Montell,Lutz Birnbaumer,Veit Flockerzi,René J. M. Bindels,Elspeth A. Bruford,Michael J. Caterina,David E. Clapham,Christian Harteneck,Stefan Heller,David Julius,Itaru Kojima,Yasuo Mori,Reinhold Penner,Dirk Prawitt,Andrew M. Scharenberg,Günter Schultz,Nobuyoshi Shimizu,Michael X. Zhu +17 more
TL;DR: The current effort to unify the TRP nomenclature focuses on three subfamilies that bear significant similarities to the founding member of this superfamily, Drosophila TRP, and which include highly related members in worms, flies, mice, and humans.
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The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel
Qing Chang,S.J.G. Hoefs,J.W.C.M. van der Kemp,Catalin N. Topala,René J. M. Bindels,Joost G. J. Hoenderop +5 more
TL;DR: It is reported here that TRPV5 is stimulated by the mammalian hormone klotho, which activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides and maintains durable calcium channel activity and membrane calcium permeability in kidney.
Journal ArticleDOI
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption.
Thomas Voets,Bernd Nilius,Susan Hoefs,Annemiete W.C.M. van der Kemp,Guy Droogmans,René J. M. Bindels,Joost G. J. Hoenderop +6 more
TL;DR: It is shown that TRPM6 is specifically localized along the apical membrane of the renal distal convoluted tubule and the brush-border membranes of the small intestine, epithelia particularly associated with active Mg2+ (re)absorption.