C
Carsten A. Wagner
Researcher at University of Zurich
Publications - 349
Citations - 17348
Carsten A. Wagner is an academic researcher from University of Zurich. The author has contributed to research in topics: Kidney & Cotransporter. The author has an hindex of 69, co-authored 318 publications receiving 15425 citations. Previous affiliations of Carsten A. Wagner include Yale University & Max Planck Society.
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Journal ArticleDOI
CATs and HATs: the SLC7 family of amino acid transporters
François Verrey,Ellen I. Closs,Carsten A. Wagner,Manuel Palacín,Hitoshi Endou,Yoshikatsu Kanai +5 more
TL;DR: Members of the CAT family transport essentially cationic amino acids by facilitated diffusion with differential trans-stimulation by intracellular substrates and may regulate the rate of NO synthesis by controlling the uptake of l-arginine as the substrate for nitric oxide synthase (NOS).
Journal ArticleDOI
Renal Vacuolar H+-ATPase
Carsten A. Wagner,Karin E. Finberg,Sylvie Breton,Vladimir Marshansky,Dennis Brown,John P. Geibel +5 more
TL;DR: The importance in final urinary acidification along the collecting system is highlighted by monogenic defects in two subunits (ATP6V0A4, ATP6V1B1) of the vacuolar H(+)-ATPase in patients with distal renal tubular acidosis.
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Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus
Anna Grifa,Carsten A. Wagner,L. D'Ambrosio,Salvatore Melchionda,Francesco Bernardi,Nuria Lopez-Bigas,Raquel Rabionet,M.L. Arbonés,Matteo Della Monica,Xavier Estivill,Leopoldo Zelante,Florian Lang,Paolo Gasparini +12 more
TL;DR: In this article, a 1,799-bp cDNA fragment containing an ORF of 261 amino acids was cloned to verify if human connexin-30 gene (Gjb6) is involved in deafness.
Journal ArticleDOI
Function and structure of heterodimeric amino acid transporters.
TL;DR: Results highlight complex interactions between the different subunits of heterodimeric amino acid transporters and suggest that despite high grades of homology, the interactions between rbAT and 4F2hc and their respective partners may be different.
Journal ArticleDOI
Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder.
Robert Kleta,Elisa Romeo,Zorica Ristic,Toshihiro Ohura,C Stuart,Mauricio Arcos-Burgos,Mital H. Dave,Carsten A. Wagner,Simone R M Camargo,Sumiko Inoue,Norio Matsuura,Amanda Helip-Wooley,Detlef Bockenhauer,Richard Warth,Isa Bernardini,Gepke Visser,Thomas Eggermann,Philip Lee,Arthit Chairoungdua,Promsuk Jutabha,Ellappan Babu,Sirinun Nilwarangkoon,Naohiko Anzai,Yoshikatsu Kanai,François Verrey,William A. Gahl,Akio Koizumi +26 more
TL;DR: The protein product of SLC6A19, the Hartnup transporter, is expressed primarily in intestine and renal proximal tubule and functions as a neutral amino acid transporter.