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Ashok Kumar
Researcher at Ipca Laboratories Ltd.
Publications - 38
Citations - 484
Ashok Kumar is an academic researcher from Ipca Laboratories Ltd.. The author has contributed to research in topics: Ion trap & Mass spectrometry. The author has an hindex of 14, co-authored 38 publications receiving 453 citations.
Papers
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Journal ArticleDOI
Development and validation of UPLC method for determination of primaquine phosphate and its impurities.
TL;DR: A new isocratic reverse phase chromatographic method was developed using UPLC for primaquine phosphate bulk drug and validated according to the regulatory guidelines with respect to specificity, precision, accuracy, linearity and robustness.
Journal ArticleDOI
Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR.
Vaijanath G. Dongre,Pradeep D. Ghugare,Pravin P. Karmuse,Dharmendra Singh,Atul N. Jadhav,Ashok Kumar +5 more
TL;DR: The focus of this study is identification and characterization of major unknown impurities in chloroquine (CQ) and hydroxychloroquine bulk drug samples using liquid chromatography/ion trap mass spectrometry (LC/IT/MS) and liquid Chromatography/time of flight mass spectrumetry ( LC/TOF/MS).
Patent
A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o
Ashok Kumar,Dharmendra Singh,Atul N. Jadhav,Navinchandra Darpan Pandya,Shankar Deepak Panmand,Ramsingh Gajendrasingh Thakur +5 more
TL;DR: In this article, a one-pot industrial process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(methyl-1H-imidazole-1-yl)methyl]-4H-carbazol-4-one of Formula-(I) was described.
Journal ArticleDOI
Solid state investigation and characterization of the polymorphic and pseudopolymorphic forms of indapamide.
Pradeep D. Ghugare,Pradeep D. Ghugare,Pradeep D. Ghugare,Vaijanath G. Dongre,Pravin P. Karmuse,Pravin P. Karmuse,Ragnesh Kumar Rana,Dharmendra Singh,Ashok Kumar,Zoeb A. Filmwala +9 more
TL;DR: Systematic analysis confirmed the existence of a polymorphic and three pseudopolymorphic forms of indapamide, a diuretic drug generally used for the treatment of hypertension, and methods of preparation of the polymorphs and pseudopoly Morphs are described.
Journal ArticleDOI
Structural elucidation of a process-related impurity in ezetimibe by LC/MS/MS and NMR.
TL;DR: A major process-related impurity associated with the synthesis of ezetimibe was detected by LC-MS and the structure was proposed to be 2-(4-hydroxybenzyl)-N,5-bis-4-fluorophenyl)-5-hydroxypentanamide, which was unambiguously confirmed with the help of the NMR and IR analyses of a synthetically obtained sample.