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Asima Bhattacharyya
Researcher at National Institute of Science Education and Research
Publications - 46
Citations - 3596
Asima Bhattacharyya is an academic researcher from National Institute of Science Education and Research. The author has contributed to research in topics: Phosphorylation & Apoptosis. The author has an hindex of 22, co-authored 40 publications receiving 2986 citations. Previous affiliations of Asima Bhattacharyya include Bose Institute & University of Virginia.
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Journal ArticleDOI
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Asima Bhattacharyya,Asima Bhattacharyya,Asima Bhattacharyya,Ranajoy Chattopadhyay,Ranajoy Chattopadhyay,Ranajoy Chattopadhyay,Sankar Mitra,Sheila E. Crowe,Sheila E. Crowe,Sheila E. Crowe +9 more
TL;DR: Unraveling the signaling events initiated at the cellular level by oxidative free radicals as well as the physiological responses to such stress is important to better understand disease pathogenesis and to develop new therapies to manage a variety of conditions for which current therapies are not always sufficient.
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Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.
Sushil Kumar Pathak,Sanchita Basu,Kunal Kumar Basu,Anirban Banerjee,Shresh Pathak,Asima Bhattacharyya,Asima Bhattacharyya,Tsuneyasu Kaisho,Manikuntala Kundu,Joyoti Basu +9 more
TL;DR: A critical function for the carboxy-terminal peptide of ESAT-6 in restricting MyD88-dependent TLR signaling emphasizes the possibility that mimetic inhibitory peptides could be used to restrict innate immune responses in situations in which prolongedTLR signaling has deleterious effects.
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Execution of Macrophage Apoptosis by PE_PGRS33 of Mycobacterium tuberculosis Is Mediated by Toll-like Receptor 2-dependent Release of Tumor Necrosis Factor-α
Sanchita Basu,Sushil Kumar Pathak,Anirban Banerjee,Shresh Pathak,Asima Bhattacharyya,Zhenhua Yang,Sarah Talarico,Manikuntala Kundu,Joyoti Basu +8 more
TL;DR: Evidence is provided that PE_PGRS33, a surface exposed protein, elicits TNF-α release from macrophages in a TLR2 (Toll-like receptor 2)-dependent manner, providing the first evidence that variations in the polymorphic repeats of the PGRS domain modulate the innate immune response.
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Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathway.
TL;DR: This work has tested the hypothesis that lipoarabinomannan (LAM) from the virulent species of Mycobacterium tuberculosis possesses the ability to modulate signaling pathways linked to cell survival and established that LAM-mediated Bad phosphorylation occurs in a PI-3K/Akt-dependent manner.
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NF-κB- and C/EBPβ-driven Interleukin-1β Gene Expression and PAK1-mediated Caspase-1 Activation Play Essential Roles in Interleukin-1β Release from Helicobacter pylori Lipopolysaccharide-stimulated Macrophages
Chaitali Basak,Sushil Kumar Pathak,Asima Bhattacharyya,Debabrata Mandal,Shresh Pathak,Manikuntala Kundu +5 more
TL;DR: These studies show for the first time that LPS-induced Rac1/PAK1 signaling leading to caspase-1 phosphorylation is crucial for caspases activation and provide detailed insight into the regulation of IL-1β gene expression by H. pylori LPS.