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Asokan Mulayath Variyath
Researcher at Memorial University of Newfoundland
Publications - 26
Citations - 2253
Asokan Mulayath Variyath is an academic researcher from Memorial University of Newfoundland. The author has contributed to research in topics: Empirical likelihood & Control chart. The author has an hindex of 11, co-authored 26 publications receiving 2060 citations. Previous affiliations of Asokan Mulayath Variyath include University of Waterloo & Texas A&M University.
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Journal ArticleDOI
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma
Terri A. Addona,Susan E. Abbatiello,Birgit Schilling,Steven J. Skates,D. R. Mani,David M. Bunk,Clifford H. Spiegelman,Lisa J. Zimmerman,Amy-Joan L. Ham,Hasmik Keshishian,Steven C. Hall,Simon Allen,Ronald K. Blackman,Christoph H. Borchers,Charles Buck,Helene L. Cardasis,Michael P. Cusack,Nathan G. Dodder,Bradford W. Gibson,Jason M. Held,Tara Hiltke,Angela M. Jackson,Eric B. Johansen,Christopher R. Kinsinger,Jing Li,Mehdi Mesri,Thomas A. Neubert,Richard K. Niles,Trenton C. Pulsipher,David F. Ransohoff,Henry Rodriguez,Paul A. Rudnick,Derek Smith,David L. Tabb,Tony J. Tegeler,Asokan Mulayath Variyath,Lorenzo Vega-Montoto,Asa Wahlander,Sofia Waldemarson,Mu Wang,Jeffrey R. Whiteaker,Lei Zhao,N. Leigh Anderson,Susan J. Fisher,Daniel C. Liebler,Amanda G. Paulovich,Fred E. Regnier,Paul Tempst,Steven A. Carr +48 more
TL;DR: A multilaboratory study to assess reproducibility, recovery, linear dynamic range and limits of detection and quantification of multiplexed, MRM-based assays, conducted by NCI-CPTAC demonstrates that these assays can be highly reproducible within and across laboratories and instrument platforms.
Journal ArticleDOI
Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography−Tandem Mass Spectrometry
David L. Tabb,Lorenzo Vega-Montoto,Lorenzo Vega-Montoto,Paul A. Rudnick,Asokan Mulayath Variyath,Asokan Mulayath Variyath,Amy-Joan L. Ham,David M. Bunk,Lisa E. Kilpatrick,Dean Billheimer,Ronald K. Blackman,Helene L. Cardasis,Helene L. Cardasis,Steven A. Carr,Karl R. Clauser,Jacob D. Jaffe,Kevin A. Kowalski,Thomas A. Neubert,Fred E. Regnier,Birgit Schilling,Tony J. Tegeler,Mu Wang,Pei Wang,Jeffrey R. Whiteaker,Lisa J. Zimmerman,Susan J. Fisher,Bradford W. Gibson,Christopher R. Kinsinger,Mehdi Mesri,Henry Rodriguez,Stephen E. Stein,Paul Tempst,Amanda G. Paulovich,Daniel C. Liebler,Cliff Spiegelman +34 more
TL;DR: The most repeatable peptides were those corresponding to conventional tryptic cleavage sites, those that produced intense MS signals, and those that resulted from proteins generating many distinct peptides.
Journal ArticleDOI
Adjusted Empirical Likelihood and its Properties
TL;DR: In this article, the authors proposed a novel adjustment to the empirical likelihood that retains all the optimality properties and guarantees a sensible value of the likelihood at any parameter value, and introduced an iterative algorithm that is guaranteed to converge.
Journal ArticleDOI
Performance Metrics for Liquid Chromatography-Tandem Mass Spectrometry Systems in Proteomics Analyses
Paul A. Rudnick,Karl R. Clauser,Lisa E. Kilpatrick,Dmitrii V. Tchekhovskoi,Pedatsur Neta,Niksa Blonder,Dean Billheimer,Ronald K. Blackman,David M. Bunk,Helene L. Cardasis,Amy-Joan L. Ham,Jacob D. Jaffe,Christopher R. Kinsinger,Mehdi Mesri,Thomas A. Neubert,Birgit Schilling,David L. Tabb,Tony J. Tegeler,Lorenzo Vega-Montoto,Asokan Mulayath Variyath,Mu Wang,Pei Wang,Jeffrey R. Whiteaker,Lisa J. Zimmerman,Steven A. Carr,Susan J. Fisher,Bradford W. Gibson,Amanda G. Paulovich,Fred E. Regnier,Henry Rodriguez,Cliff Spiegelman,Paul Tempst,Daniel C. Liebler,Stephen E. Stein +33 more
TL;DR: 46 system performance metrics for monitoring chromatographic performance, electrospray source stability, MS1 and MS2 signals, dynamic sampling of ions for MS/MS, and peptide identification are described.
Journal ArticleDOI
Interlaboratory Study Characterizing a Yeast Performance Standard for Benchmarking LC-MS Platform Performance
Amanda G. Paulovich,Dean Billheimer,Amy-Joan L. Ham,Lorenzo Vega-Montoto,Lorenzo Vega-Montoto,Paul A. Rudnick,David L. Tabb,Pei Wang,Ronald K. Blackman,David M. Bunk,Helene L. Cardasis,Karl R. Clauser,Christopher R. Kinsinger,Birgit Schilling,Tony J. Tegeler,Asokan Mulayath Variyath,Mu Wang,Jeffrey R. Whiteaker,Lisa J. Zimmerman,David Fenyö,Steven A. Carr,Susan J. Fisher,Bradford W. Gibson,Mehdi Mesri,Thomas A. Neubert,Fred E. Regnier,Henry Rodriguez,Cliff Spiegelman,Cliff Spiegelman,Stephen E. Stein,Paul Tempst,Daniel C. Liebler +31 more
TL;DR: A standard operating protocol for large scale production of the yeast performance standard is described and aliquots are offered to the community through the National Institute of Standards and Technology where the yeast proteome is under development as a certified reference material to meet the long term needs of the community.