L
Lisa J. Zimmerman
Researcher at Vanderbilt University
Publications - 57
Citations - 9022
Lisa J. Zimmerman is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Proteomics & Glycosylation. The author has an hindex of 33, co-authored 57 publications receiving 7123 citations. Previous affiliations of Lisa J. Zimmerman include Vanderbilt University Medical Center.
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Journal ArticleDOI
Reassessment of Exosome Composition
Dennis K. Jeppesen,Aidan M. Fenix,Jeffrey L. Franklin,James N. Higginbotham,Qin Zhang,Lisa J. Zimmerman,Daniel C. Liebler,Jie Ping,Qi Liu,Rachel Evans,William H. Fissell,James G. Patton,Leonard H. Rome,Dylan T. Burnette,Robert J. Coffey,Robert J. Coffey,Robert J. Coffey +16 more
TL;DR: High-resolution density gradient fractionation and direct immunoaffinity capture are employed to precisely characterize the RNA, DNA, and protein constituents of exosomes and other non-vesicle material and show that small extracellular vesicles are not vehicles of active DNA release.
Journal ArticleDOI
Proteogenomic characterization of human colon and rectal cancer
Bing Zhang,Jing Wang,Xiaojing Wang,Jing Zhu,Qi Liu,Zhiao Shi,Matthew C. Chambers,Lisa J. Zimmerman,Kent Shaddox,Sangtae Kim,Sherri R. Davies,Sean Wang,Pei Wang,Christopher R. Kinsinger,Robert Rivers,Henry Rodriguez,R. Reid Townsend,Matthew J. Ellis,Steven A. Carr,Steven A. Carr,David L. Tabb,Robert J. Coffey,Robbert J.C. Slebos,Daniel C. Liebler,Michael A. Gillette,Karl R. Klauser,Eric Kuhn,D. R. Mani,Philipp Mertins,Karen A. Ketchum,Amanda G. Paulovich,Jeffrey R. Whiteaker,Nathan Edwards,Peter B. McGarvey,Subha Madhavan,Daniel W. Chan,Akhilesh Pandey,Ie Ming Shih,Hui Zhang,Zhen Zhang,Heng Zhu,Gordon Whiteley,Steven J. Skates,Forest M. White,Douglas A. Levine,Emily S. Boja,Tara Hiltke,Mehdi Mesri,Kenna M. Shaw,Stephen E. Stein,David Fenyö,Tao Liu,Jason E. McDermott,Samuel H. Payne,Karin D. Rodland,Richard D. Smith,Paul A. Rudnick,Michael Snyder,Yingming Zhao,Xian Chen,David F. Ransohoff,Andrew N. Hoofnagle,Melinda E. Sanders,Yue Wang,Li Ding +64 more
TL;DR: Integrated proteogenomic analysis provides functional context to interpret genomic abnormalities and affords a new paradigm for understanding cancer biology.
Journal ArticleDOI
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma
Terri A. Addona,Susan E. Abbatiello,Birgit Schilling,Steven J. Skates,D. R. Mani,David M. Bunk,Clifford H. Spiegelman,Lisa J. Zimmerman,Amy-Joan L. Ham,Hasmik Keshishian,Steven C. Hall,Simon Allen,Ronald K. Blackman,Christoph H. Borchers,Charles Buck,Helene L. Cardasis,Michael P. Cusack,Nathan G. Dodder,Bradford W. Gibson,Jason M. Held,Tara Hiltke,Angela M. Jackson,Eric B. Johansen,Christopher R. Kinsinger,Jing Li,Mehdi Mesri,Thomas A. Neubert,Richard K. Niles,Trenton C. Pulsipher,David F. Ransohoff,Henry Rodriguez,Paul A. Rudnick,Derek Smith,David L. Tabb,Tony J. Tegeler,Asokan Mulayath Variyath,Lorenzo Vega-Montoto,Asa Wahlander,Sofia Waldemarson,Mu Wang,Jeffrey R. Whiteaker,Lei Zhao,N. Leigh Anderson,Susan J. Fisher,Daniel C. Liebler,Amanda G. Paulovich,Fred E. Regnier,Paul Tempst,Steven A. Carr +48 more
TL;DR: A multilaboratory study to assess reproducibility, recovery, linear dynamic range and limits of detection and quantification of multiplexed, MRM-based assays, conducted by NCI-CPTAC demonstrates that these assays can be highly reproducible within and across laboratories and instrument platforms.
Journal ArticleDOI
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
Anne Le,Andrew N. Lane,Max Hamaker,Sminu Bose,Arvin M. Gouw,Joseph Barbi,Takashi Tsukamoto,Camilio J. Rojas,Barbara S. Slusher,Haixia Zhang,Lisa J. Zimmerman,Daniel C. Liebler,Robbert J.C. Slebos,Pawel Lorkiewicz,Richard M. Higashi,Teresa W.-M. Fan,Chi V. Dang +16 more
TL;DR: The metabolic responses of a MYC-inducible human Burkitt lymphoma model P493 cell line to aerobic and hypoxic conditions, and to glucose deprivation, are determined using stable isotope-resolved metabolomics to demonstrate an alternative energy-generating glutaminolysis pathway involving a glucose-independent TCA cycle.
Journal ArticleDOI
Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography−Tandem Mass Spectrometry
David L. Tabb,Lorenzo Vega-Montoto,Lorenzo Vega-Montoto,Paul A. Rudnick,Asokan Mulayath Variyath,Asokan Mulayath Variyath,Amy-Joan L. Ham,David M. Bunk,Lisa E. Kilpatrick,Dean Billheimer,Ronald K. Blackman,Helene L. Cardasis,Helene L. Cardasis,Steven A. Carr,Karl R. Clauser,Jacob D. Jaffe,Kevin A. Kowalski,Thomas A. Neubert,Fred E. Regnier,Birgit Schilling,Tony J. Tegeler,Mu Wang,Pei Wang,Jeffrey R. Whiteaker,Lisa J. Zimmerman,Susan J. Fisher,Bradford W. Gibson,Christopher R. Kinsinger,Mehdi Mesri,Henry Rodriguez,Stephen E. Stein,Paul Tempst,Amanda G. Paulovich,Daniel C. Liebler,Cliff Spiegelman +34 more
TL;DR: The most repeatable peptides were those corresponding to conventional tryptic cleavage sites, those that produced intense MS signals, and those that resulted from proteins generating many distinct peptides.