A
Assia Derfoul
Researcher at Thomas Jefferson University
Publications - 9
Citations - 1405
Assia Derfoul is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Mesenchymal stem cell & Transactivation. The author has an hindex of 7, co-authored 8 publications receiving 1348 citations.
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Journal ArticleDOI
A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells.
W-J Wan-Ju Li,Richard Tuli,Chukwuka Okafor,Assia Derfoul,Keith G. Danielson,David J. Hall,Rocky S. Tuan +6 more
TL;DR: The findings reported here suggest that the PCL NFS is a practical carrier for MSC transplantation, and represents a candidate scaffold for cell-based tissue engineering approaches to cartilage repair.
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Glucocorticoids Promote Chondrogenic Differentiation of Adult Human Mesenchymal Stem Cells by Enhancing Expression of Cartilage Extracellular Matrix Genes
TL;DR: The effects of dexamethasone (DEX) on chondrogenic differentiation of hMSCs in the presence or absence of DEX, transforming growth factor‐β (TGF‐ β), or DEX plus TGF‐β are examined to suggest GCs may play an important role in the maintenance of cartilage homeostasis.
Journal ArticleDOI
Optimization of high-efficiency transfection of adult human mesenchymal stem cells in vitro.
Hana Haleem-Smith,Assia Derfoul,Chukwuka C Okafor,Richard Tuli,Douglas Olsen,David J. Hall,Rocky S. Tuan +6 more
TL;DR: A significant enhancement of GFP level was seen, indicating the ability of the transfected cells to differentiate into chondrocytes and express cartilage-specific genes, such as Col2a1.
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Regulation of the human Na/K-ATPase beta1 gene promoter by mineralocorticoid and glucocorticoid receptors.
TL;DR: Data indicate that the 21-base pair sequence represents a true MRE/GRE and that optimal activation of the human Na/K-ATPase β1 promoter is controlled by mineralocorticoid and glucocortioid hormones.
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Inhibition of Glucocorticoid-induced Apoptosis in 697 Pre-B Lymphocytes by the Mineralocorticoid Receptor N-terminal Domain
TL;DR: Stable expression of NTD-MR blocks apoptosis and inhibits proteolytic processing of pro-caspases-3, -8, and -9 and poly(ADP-ribose) polymerase in GC-sensitive pre-B lymphoma cells, providing a potential mechanism for the observed inhibition of cytochromec and Smac release from the mitochondria of N TD-MR cells and resultant resistance to GC-induced apoptosis.