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Astrid Herwig
Researcher at University of Marburg
Publications - 21
Citations - 1708
Astrid Herwig is an academic researcher from University of Marburg. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 17, co-authored 20 publications receiving 1543 citations. Previous affiliations of Astrid Herwig include Friedrich Loeffler Institute.
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Journal ArticleDOI
Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus
TL;DR: It is shown that adaptive mutations D701N in PB2 and N319K in NP enhance binding of these proteins to importin α1 in mammalian cells, demonstrating that adaptation of the viral polymerase to the nuclear import machinery plays an important role in interspecies transmission of influenza virus.
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Interdependence of hemagglutinin glycosylation and neuraminidase as regulators of influenza virus growth: a study by reverse genetics.
TL;DR: It is demonstrated that N-glycans flanking the receptor-binding site of the HA molecule are potent regulators of influenza virus growth, with the glycan at Asn149 being dominant and that at AsN123 being less effective.
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Inclusion Bodies Are a Site of Ebolavirus Replication
Thomas Hoenen,Reed S. Shabman,Allison Groseth,Allison Groseth,Astrid Herwig,Michaela Weber,Gordian Schudt,Olga Dolnik,Christopher F. Basler,Stephan Becker,Heinz Feldmann +10 more
TL;DR: It is concluded that, rather than being inert aggregates of nucleocapsids, ebolavirus inclusion bodies are in fact complex and dynamic structures and an important site at which viral RNA replication takes place.
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Both matrix proteins of Ebola virus contribute to the regulation of viral genome replication and transcription.
TL;DR: Systems that allow the independent monitoring of viral transcription and replication, based on qRT-PCR and a replication-deficient minigenome, show that VP24 regulates not only viral genome replication, but also transcription, and for the first time that VP40 is also involved in regulating these processes.
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A Novel Life Cycle Modeling System for Ebola Virus Shows a Genome Length-Dependent Role of VP24 in Virus Infectivity
Ari Watt,Felicien Moukambi,Logan Banadyga,Allison Groseth,Julie Callison,Astrid Herwig,Hideki Ebihara,Heinz Feldmann,Thomas Hoenen +8 more
TL;DR: A novel reverse genetics-based system allowing continuous passaging of infectious trVLPs containing a tetracistronic minigenome that encodes a reporter and the viral proteins VP40, VP24, and GP1,2 is developed, and a comprehensive model for the function of VP24 in nucleocapsid assembly is proposed.