R
Reed S. Shabman
Researcher at J. Craig Venter Institute
Publications - 51
Citations - 2959
Reed S. Shabman is an academic researcher from J. Craig Venter Institute. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 28, co-authored 50 publications receiving 2509 citations. Previous affiliations of Reed S. Shabman include ATCC & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
DENV inhibits type I IFN production in infected cells by cleaving human STING.
Sebastian Aguirre,Ana M. Maestre,Sarah Pagni,Jenish R. Patel,Timothy Savage,Delia Gutman,Kevin Maringer,Dabeiba Bernal-Rubio,Reed S. Shabman,Viviana Simon,Juan R. Rodriguez-Madoz,Juan R. Rodriguez-Madoz,Lubbertus C. F. Mulder,Glen N. Barber,Ana Fernandez-Sesma +14 more
TL;DR: It is shown that DENV NS2B3 is not able to degrade the mouse version of STING, a phenomenon that severely restricts the replication of DENV in mouse cells, suggesting that STING plays a key role in the inhibition ofDENV infection and spread in mice.
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Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells
James R. Bowen,James R. Bowen,Kendra M. Quicke,Kendra M. Quicke,Mohan S. Maddur,Mohan S. Maddur,Justin T. O’Neal,Justin T. O’Neal,Circe E. McDonald,Circe E. McDonald,Nadia Fedorova,Vinita Puri,Reed S. Shabman,Bali Pulendran,Bali Pulendran,Mehul S. Suthar,Mehul S. Suthar +16 more
TL;DR: Combined, the findings show that ZIKV subverts DC immunogenicity during infection, in part through evasion of type I IFN responses, but that the RLR signaling pathway is still capable of inducing an antiviral state, and therefore may serve as a antiviral therapeutic target.
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Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis
Thomas E. Morrison,Alan C. Whitmore,Reed S. Shabman,Brett A. Lidbury,Suresh Mahalingam,Mark T. Heise +5 more
TL;DR: The mouse model of RRV disease is established as a useful system for the identification of viral and host factors that contribute to alphavirus-induced arthritis and myositis.
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Inclusion Bodies Are a Site of Ebolavirus Replication
Thomas Hoenen,Reed S. Shabman,Allison Groseth,Allison Groseth,Astrid Herwig,Michaela Weber,Gordian Schudt,Olga Dolnik,Christopher F. Basler,Stephan Becker,Heinz Feldmann +10 more
TL;DR: It is concluded that, rather than being inert aggregates of nucleocapsids, ebolavirus inclusion bodies are in fact complex and dynamic structures and an important site at which viral RNA replication takes place.
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An intrinsically disordered peptide from ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions
Daisy W. Leung,Dominika Borek,Priya Luthra,Jennifer M. Binning,Manu Anantpadma,Gai Liu,Ian B. Harvey,Zhaoming Su,Ariel C. Endlich-Frazier,Juanli Pan,Reed S. Shabman,Wah Chiu,Robert A. Davey,Zbyszek Otwinowski,Christopher F. Basler,Gaya K. Amarasinghe +15 more
TL;DR: The structure of the NPBP/ΔNPNTD complex, solved to 3.7 Å resolution, reveals how NPBP peptide occludes a large surface area that is important for NP-NP and NP-RNA interactions and for viral RNA synthesis.