G
Gülsah Gabriel
Researcher at Heinrich Pette Institute
Publications - 68
Citations - 3131
Gülsah Gabriel is an academic researcher from Heinrich Pette Institute. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 24, co-authored 57 publications receiving 2584 citations. Previous affiliations of Gülsah Gabriel include University of Veterinary Medicine Vienna & Leibniz Association.
Papers
More filters
Journal ArticleDOI
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
TL;DR: Specific mutations in SC35M polymerase considerably increase its activity in mammalian cells, correlating with high virulence in mice, demonstrating convergent evolution in nature and may be a prerequisite for adaptation to a new host paving the way for new pandemic viruses.
Journal ArticleDOI
Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus
TL;DR: It is shown that adaptive mutations D701N in PB2 and N319K in NP enhance binding of these proteins to importin α1 in mammalian cells, demonstrating that adaptation of the viral polymerase to the nuclear import machinery plays an important role in interspecies transmission of influenza virus.
Journal ArticleDOI
Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus
Gülsah Gabriel,Karin Klingel,Anna Otte,Swantje Thiele,Ben Hudjetz,Gökhan Arman-Kalcek,Martina Sauter,Tatiana Shmidt,Franziska Rother,Sigrid Baumgarte,Björn Keiner,Enno Hartmann,Michael Bader,George G. Brownlee,Ervin Fodor,Hans-Dieter Klenk +15 more
TL;DR: Differences in importin-α specificity are determinants of host range underlining the importance of the nuclear envelope in interspecies transmission.
Journal ArticleDOI
TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice
Carolin Tarnow,Géraldine Engels,Annika Arendt,Folker Schwalm,Hanna Sediri,Annette Preuss,Peter S. Nelson,Wolfgang Garten,Hans-Dieter Klenk,Gülsah Gabriel,Eva Böttcher-Friebertshäuser +10 more
TL;DR: It is shown that knockout mice that do not express the HA-activating protease TMPRSS2 are resistant to pulmonary disease with lethal outcome when infected with influenza A viruses of subtypes H7N9 and H1N1, whereas they are not protected from lethal H3N2 virus infection.
Journal ArticleDOI
Differential Polymerase Activity in Avian and Mammalian Cells Determines Host Range of Influenza Virus
TL;DR: The increase in levels of transcription and replication of SC35M in mammalian cells was linked to a decrease in avian cells, indicating the efficiency of the viral polymerase is a determinant of both host specificity and pathogenicity.