A
Astrid R. Mach-Aigner
Researcher at Vienna University of Technology
Publications - 71
Citations - 1956
Astrid R. Mach-Aigner is an academic researcher from Vienna University of Technology. The author has contributed to research in topics: Trichoderma reesei & Gene. The author has an hindex of 24, co-authored 62 publications receiving 1521 citations. Previous affiliations of Astrid R. Mach-Aigner include Wageningen University and Research Centre.
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Journal ArticleDOI
Transcriptional regulation of xyr1, encoding the main regulator of the xylanolytic and cellulolytic enzyme system in Hypocrea jecorina.
Astrid R. Mach-Aigner,Marion E. Pucher,Matthias G. Steiger,Gudrun E. Bauer,Sonja J. Preis,Robert L. Mach +5 more
TL;DR: The corresponding xylanolytic enzyme activities are clearly elevated in a constitutively xyr1-expressing strain, emphasizing this factor as an auspicious target for genetically engineered strain improvement.
Journal ArticleDOI
Transformation System for Hypocrea jecorina (Trichoderma reesei) That Favors Homologous Integration and Employs Reusable Bidirectionally Selectable Markers
Matthias G. Steiger,Marika Vitikainen,Pekka Uskonen,Kurt Brunner,Gerhard Adam,Tiina Pakula,Merja Penttilä,Markku Saloheimo,Robert L. Mach,Astrid R. Mach-Aigner +9 more
TL;DR: A transformation system that allows highly efficient gene targeting by using a tmus53 (human LIG4 homolog) deletion strain and permits the unlimited reuse of the same marker by employing a Cre/loxP-based excision system is reported.
Journal ArticleDOI
Mutation of the Xylanase regulator 1 causes a glucose blind hydrolase expressing phenotype in industrially used Trichoderma strains.
Christian Derntl,Loreta Gudynaite-Savitch,Sophie Calixte,Theresa White,Robert L. Mach,Astrid R. Mach-Aigner +5 more
TL;DR: A single point mutation in the gene encoding the Xylanase regulator 1 (Xyr1) is responsible for this strong deregulation of endo-xylanase expression and, moreover, a highly elevated basal level of cellulase expression.
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An accurate normalization strategy for RT-qPCR in Hypocrea jecorina (Trichoderma reesei)
TL;DR: The most stable genes amongst six potential reference genes in 34 samples from diverse cultivation conditions were evaluated, and sar1 encoding for a small GTPase was found to be the most stable gene, whereas act encoding for actin was not amongst the best validated ones.
Journal ArticleDOI
The Post-genomic Era of Trichoderma reesei: What's Next?
Vijai Kumar Gupta,Andrei Stecca Steindorff,Renato Graciano de Paula,Rafael Silva-Rocha,Astrid R. Mach-Aigner,Robert L. Mach,Roberto Nascimento Silva +6 more
TL;DR: An overview of new findings in the gene expression regulation network of T. reesei is presented and how synthetic biology strategies can be used to create engineered promoters to efficiently synthesize enzymes for biomass degradation to produce bioethanol is presented.