A
Astrid Zwerdling
Researcher at University of Buenos Aires
Publications - 12
Citations - 749
Astrid Zwerdling is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Antigen & Vaccination. The author has an hindex of 10, co-authored 12 publications receiving 697 citations.
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Journal ArticleDOI
Lipoproteins, Not Lipopolysaccharide, Are the Key Mediators of the Proinflammatory Response Elicited by Heat-Killed Brucella abortus
Guillermo H. Giambartolomei,Astrid Zwerdling,Juliana Cassataro,Laura Bruno,Carlos A. Fossati,Mario T. Philipp +5 more
TL;DR: It is submitted that LPS is not the cause of inflammation in brucellosis; rather, lipoproteins of this organism trigger the production of proinflammatory cytokines, and TLR2 is involved in this process.
Journal ArticleDOI
Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection.
Karina A. Pasquevich,Silvia M. Estein,Clara García Samartino,Astrid Zwerdling,Lorena M. Coria,Paula Barrionuevo,Carlos A. Fossati,Guillermo H. Giambartolomei,Juliana Cassataro +8 more
TL;DR: Flow cytometric analysis showed that immunization with U-Omp16 or U- omp19 induced antigen-specific CD4+ as well as CD8+ T cells producing gamma interferon, indicating that both cell types are mediating immune protection.
Journal ArticleDOI
An Oral Vaccine Based on U-Omp19 Induces Protection against B. abortus Mucosal Challenge by Inducing an Adaptive IL-17 Immune Response in Mice
Karina A. Pasquevich,Andrés E. Ibañez,Lorena M. Coria,Clara García Samartino,Silvia M. Estein,Astrid Zwerdling,Paula Barrionuevo,Fernanda S. Oliveira,Christine Seither,Heribert Warzecha,Sergio C. Oliveira,Guillermo H. Giambartolomei,Juliana Cassataro +12 more
TL;DR: The results indicate that an oral unadjuvanted vaccine based on U-Omp19 induces protection against a mucosal challenge with Brucella abortus by inducing an adaptive IL-17 immune response and indicate different and important new aspects i) IL- 17 does not contribute to reduce the bacterial burden in non vaccinated mice and ii) IL -17 plays a central role in vaccine mediated anti-Brucella mucosal immunity.
Journal ArticleDOI
Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2.
Paula Barrionuevo,Juliana Cassataro,M. Victoria Delpino,Astrid Zwerdling,Karina A. Pasquevich,Clara García Samartino,Jorge C. Wallach,Carlos A. Fossati,Guillermo H. Giambartolomei +8 more
TL;DR: Results indicate that there is a mechanism by which B. abortus may prevent recognition by T cells to evade host immunity and establish a chronic infection.
Journal ArticleDOI
The Protein Moiety of Brucella abortus Outer Membrane Protein 16 Is a New Bacterial Pathogen-Associated Molecular Pattern That Activates Dendritic Cells In Vivo, Induces a Th1 Immune Response, and Is a Promising Self-Adjuvanting Vaccine against Systemic and Oral Acquired Brucellosis
Karina A. Pasquevich,Clara García Samartino,Lorena M. Coria,Silvia M. Estein,Astrid Zwerdling,Andrés E. Ibañez,Paula Barrionuevo,Fernanda S. Oliveira,Natalia B. Carvalho,Julia Borkowski,Sergio C. Oliveira,Heribert Warzecha,Guillermo H. Giambartolomei,Juliana Cassataro +13 more
TL;DR: It is demonstrated that Omp16 administered by the i.p. route confers significant protection against B. abortus infection and that the protective response evoked is independent of the protein lipidation, indicating that a plant-based oral vaccine expressing U-Omp16 could be a valuable approach to controlling this disease.