J
Juliana Cassataro
Researcher at National Scientific and Technical Research Council
Publications - 67
Citations - 2367
Juliana Cassataro is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 27, co-authored 60 publications receiving 2162 citations. Previous affiliations of Juliana Cassataro include University of Buenos Aires.
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Journal ArticleDOI
Lipoproteins, Not Lipopolysaccharide, Are the Key Mediators of the Proinflammatory Response Elicited by Heat-Killed Brucella abortus
Guillermo H. Giambartolomei,Astrid Zwerdling,Juliana Cassataro,Laura Bruno,Carlos A. Fossati,Mario T. Philipp +5 more
TL;DR: It is submitted that LPS is not the cause of inflammation in brucellosis; rather, lipoproteins of this organism trigger the production of proinflammatory cytokines, and TLR2 is involved in this process.
Journal ArticleDOI
Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection.
Karina A. Pasquevich,Silvia M. Estein,Clara García Samartino,Astrid Zwerdling,Lorena M. Coria,Paula Barrionuevo,Carlos A. Fossati,Guillermo H. Giambartolomei,Juliana Cassataro +8 more
TL;DR: Flow cytometric analysis showed that immunization with U-Omp16 or U- omp19 induced antigen-specific CD4+ as well as CD8+ T cells producing gamma interferon, indicating that both cell types are mediating immune protection.
Journal ArticleDOI
A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response.
Juliana Cassataro,Carlos A. Velikovsky,Silvia de la Barrera,Silvia M. Estein,Laura Bruno,Raul A. Bowden,Karina A. Pasquevich,Carlos A. Fossati,Guillermo H. Giambartolomei +8 more
TL;DR: In vivo depletion of T-cell subsets showed that the pCIOmp31-induced protection against Brucella infection is mediated predominantly by CD8+ T cells, although CD4+T cells also contribute.
Journal ArticleDOI
Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection.
Juliana Cassataro,Silvia M. Estein,Karina A. Pasquevich,Carlos A. Velikovsky,Silvia de la Barrera,Raul A. Bowden,Carlos A. Fossati,Guillermo H. Giambartolomei +7 more
TL;DR: The results indicate that rOmp31 could be a useful candidate for the development of subunit vaccines against B. melitensis and B. ovis, and a known exposed region from Omp31 on the Brucella membrane, a peptide that contains amino acids 48 to 74 of Omp 31.
Journal ArticleDOI
A DNA Vaccine Encoding Lumazine Synthase from Brucella abortus Induces Protective Immunity in BALB/c Mice
Carlos A. Velikovsky,Juliana Cassataro,Guillermo H. Giambartolomei,Fernando Alberto Goldbaum,Silvia M. Estein,Raul A. Bowden,Laura Bruno,Carlos A. Fossati,Moisés Spitz +8 more
TL;DR: The data suggest that pcDNA-BLS is a good immunogen for the production of humoral and cell-mediated responses in mice and is a candidate for use in future studies of vaccination against brucellosis.