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Atsushi Fukushima
Researcher at St. Marianna University School of Medicine
Publications - 16
Citations - 1098
Atsushi Fukushima is an academic researcher from St. Marianna University School of Medicine. The author has contributed to research in topics: Hypothalamus & Insulin. The author has an hindex of 9, co-authored 16 publications receiving 979 citations. Previous affiliations of Atsushi Fukushima include Monash University & National Institute for Environmental Studies.
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Journal ArticleDOI
Reactive oxygen species enhance insulin sensitivity.
Kim Loh,Haiyang Deng,Atsushi Fukushima,Xiaochu Cai,Benoit Boivin,Sandra Galic,Clinton R. Bruce,Benjamin J. Shields,Beata Skiba,Lisa M Ooms,Nigel K. Stepto,Ben Jing Wu,Christina Anne Mitchell,Nicholas K. Tonks,Matthew J. Watt,Mark A. Febbraio,Peter J Crack,Sofianos Andrikopoulos,Tony Tiganis +18 more
TL;DR: In this article, the authors reported that mice lacking one of the key enzymes involved in the elimination of physiological ROS, glutathione peroxidase 1 (Gpx1), were protected from high-fat-diet-induced insulin resistance.
Journal ArticleDOI
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance
Kim Loh,Atsushi Fukushima,Xinmei Mary Zhang,Sandra Galic,Dana I Briggs,Pablo J. Enriori,Stephanie E. Simonds,Florian Wiede,Alexander Reichenbach,Christine Hauser,Natalie A. Sims,Kendra K. Bence,Sheng Zhang,Zhong Yin Zhang,Barbara B. Kahn,Benjamin G. Neel,Zane B. Andrews,Michael A. Cowley,Tony Tiganis +18 more
TL;DR: It is shown that mice that lack TCPTP in neuronal cells have enhanced leptin sensitivity and are resistant to high-fat-diet-induced weight gain and the development of leptin resistance.
Journal ArticleDOI
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Tin-Tin-Win-Shwe,Dai Mitsushima,Shoji Yamamoto,Atsushi Fukushima,Toshiya Funabashi,Takahiro Kobayashi,Hidekazu Fujimaki +6 more
TL;DR: It is suggested that nanoparticle CB may modulate the extracellular amino acid neurotransmitter levels and proinflammatory cytokine IL-1 beta mRNA expressions synergistically with LTA in the mice olfactory bulb.
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T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
Atsushi Fukushima,Kim Loh,Sandra Galic,Barbara C Fam,Benjamin J. Shields,Florian Wiede,Michel L. Tremblay,Matthew J. Watt,Sofianos Andrikopoulos,Tony Tiganis +9 more
TL;DR: Liver TCPTP antagonises both insulin and STAT3 signaling pathways to regulate gluconeogenic gene expression and hepatic glucose output.
Journal ArticleDOI
Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2
Esteban Nicolas Gurzov,Melanie Tran,Manuel A. Fernandez-Rojo,Troy L. Merry,Xinmei Zhang,Yang Xu,Atsushi Fukushima,Michael J. Waters,Matthew J. Watt,Sofianos Andrikopoulos,Benjamin G. Neel,Benjamin G. Neel,Tony Tiganis +12 more
TL;DR: It is reported that oxidative stress accompanying obesity inactivates protein-tyrosine phosphatases in the liver to activate select signaling pathways that exacerbate disease progression, and defines a mechanism for the development of selective insulin resistance with wide-ranging implications for diseases characterized by oxidative stress.