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Avelina Tortosa
Researcher at University of Barcelona
Publications - 46
Citations - 2614
Avelina Tortosa is an academic researcher from University of Barcelona. The author has contributed to research in topics: Gerbil & Apoptosis. The author has an hindex of 26, co-authored 45 publications receiving 2351 citations. Previous affiliations of Avelina Tortosa include Bellvitge University Hospital & Harvard University.
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Journal ArticleDOI
High TGFβ-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene
Alejandra Bruna,Rachel S. Darken,Federico Rojo,Alberto Ocaña,Silvia Peñuelas,Alexandra Arias,Raquel Paris,Avelina Tortosa,Jaume Mora,José Baselga,Joan Seoane,Joan Seoane +11 more
TL;DR: It is demonstrated that high TGFbeta-Smad activity is present in aggressive, highly proliferative gliomas and confers poor prognosis in patients with glioma.
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Prognostic Significance of O6-Methylguanine-DNA Methyltransferase Determined by Promoter Hypermethylation and Immunohistochemical Expression in Anaplastic Gliomas
Marta Brell,Avelina Tortosa,Eugenia Verger,Juan Miguel Gil,Nuria Viñolas,Salvador Villà,Juan José Acebes,Lluís Caral,Teresa Pujol,Isidro Ferrer,Teresa Ribalta,Francesc Graus +11 more
TL;DR: A correlation between MGMT protein expression and survival in those patients who received chemotherapy is observed, suggesting that the absence of MGMT expression is a positive predictive marker in patients with anaplastic glioma.
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Overcoming drug resistance by enhancing apoptosis of tumor cells.
TL;DR: In this paper, the authors review the molecular changes that have the potential to cause apoptotic dysregulation, including activation of anti-apoptotic factors (Bcl-2, BCLX(L), Bfl1/A1 etc.), inactivation of pro-apopotic effectors (p53, p53 pathway), and reinforcement of survival signals (Survivin, FLIP, NF-kappaB etc).
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Ki-67 proliferative index predicts clinical outcome in patients with atypical or anaplastic meningioma.
TL;DR: The multivariate analysis demonstrated that Ki‐67 labeling index is the only independent predictor of both tumor recurrence and overall survival and this predictive value was maintained in both patients with atypical and patients with anaplastic meningioma.
Journal ArticleDOI
Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil
Isidro Ferrer,Avelina Tortosa,Alfons Macaya,Angels Sierra,Dolores Moreno,Francina Munell,Rosa Blanco,Waney Squier +7 more
TL;DR: In situ labeling of nuclear DNA fragmentation demonstrated stained punctate chromatin condensation in a few degenerating cells at 48 hours post‐ischemia in rats subjected to permanent bilateral forebrain ischemia.