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Isidre Ferrer
Researcher at University of Barcelona
Publications - 314
Citations - 19010
Isidre Ferrer is an academic researcher from University of Barcelona. The author has contributed to research in topics: Oxidative stress & Neurodegeneration. The author has an hindex of 74, co-authored 314 publications receiving 16519 citations. Previous affiliations of Isidre Ferrer include Carlos III Health Institute & Ministry of Science and Innovation.
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Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat
Claudia Carrieri,Laura Cimatti,Marta Biagioli,Marta Biagioli,Anne Beugnet,Silvia Zucchelli,Silvia Zucchelli,Stefania Fedele,Elisa Pesce,Isidre Ferrer,Licio Collavin,Licio Collavin,Claudio Santoro,Alistair R. R. Forrest,Piero Carninci,Stefano Biffo,Elia Stupka,Stefano Gustincich,Stefano Gustincich +18 more
TL;DR: This work identifies a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases, and identifies a new functional class of lncRNAs.
Journal ArticleDOI
Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease
Isidre Ferrer,Mercé Boada Rovira,María Luisa Sánchez Guerra,María Jesús Rey,Frederic Costa-Jussá +4 more
TL;DR: The present neuropathological study reports the second case of menigoencephalitis following immunization with amyloid‐β peptide in AD, and focuses on exploring mechanisms underlying decreased tau pathology in relation to amyliod deposit regression, and possible molecular bases involved in the inflammatory response following Immunization.
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MicroRNA profiling of Parkinson’s disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
Elena Miñones-Moyano,Sílvia Porta,Geòrgia Escaramís,Raquel Rabionet,Susana Iraola,Birgit Kagerbauer,Yolanda Espinosa-Parrilla,Isidre Ferrer,Isidre Ferrer,Xavier Estivill,Eulàlia Martí +10 more
TL;DR: It is proposed that early deregulation of miR-34b/c in PD triggers downstream transcriptome alterations underlying mitochondrial dysfunction and oxidative stress, which ultimately compromise cell viability.
Journal ArticleDOI
A DNA methylation fingerprint of 1628 human samples
Augustin F. Fernandez,Yassen Assenov,José I. Martín-Subero,Balázs Bálint,Reiner Siebert,Hiroaki Taniguchi,Hiroyuki Yamamoto,Manuel Hidalgo,Manuel Hidalgo,Aik Choon Tan,Oliver Galm,Isidre Ferrer,Montse Sanchez-Cespedes,Alberto Villanueva,Javier Carmona,Jose V. Sanchez-Mut,María Berdasco,Victor Moreno,Gabriel Capellá,David Monk,Esteban Ballestar,Santiago Ropero,Ramon Martinez,Marta Sanchez-Carbayo,Felipe Prosper,Xabier Agirre,Mario F. Fraga,Mario F. Fraga,Osvaldo Graña,Luis A. Pérez-Jurado,Jaume Mora,Susana Puig,Jaime Prat,Lina Badimon,Annibale Alessandro Puca,Stephen J. Meltzer,Thomas Lengauer,John Bridgewater,Christoph Bock,Manel Esteller +39 more
TL;DR: The DNA methylation patterns identified across the largest spectrum of samples, tissues, and diseases reported to date constitute a baseline for developing higher-resolutionDNA methylation maps and provide important clues concerning the contribution of CpG methylation to tissue identity and its changes in the most prevalent human diseases.
Journal ArticleDOI
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis.
Ekaterina V. Ilieva,Victoria Ayala,Mariona Jové,Esther Dalfó,Daniel Cacabelos,Mònica Povedano,Maria Josep Bellmunt,Isidre Ferrer,Reinald Pamplona,Manuel Portero-Otin +9 more
TL;DR: It was found that protein oxidative damage was strongly associated to ALS-specific changes in fatty acid concentrations, specifically of n-3 series, and in the amount of mitochondrial components as respiratory complexes I and III, suggesting a mitochondrial dysfunction leading to increased free radical production.