A
Avram Hershko
Researcher at California Institute of Technology
Publications - 3
Citations - 693
Avram Hershko is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Gene & Peptide sequence. The author has an hindex of 2, co-authored 3 publications receiving 670 citations.
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A heat-stable polypeptide component of an ATP-Dependent Proteolytic System from reticullocytes
TL;DR: The degradation of denatured globin in reticulocyte lysates is markedly stimulated by ATP and this system has now been resolved into two components, designated fractions I and II, in the order of their elution from DEAE-cellulose.
Journal ArticleDOI
The mouse and human genes encoding the recognition component of the N-end rule pathway.
Yong Tae Kwon,Yuval Reiss,Victor A. Fried,Avram Hershko,Jeong Kyo Yoon,David K. Gonda,Pitchai Sangan,Neal G. Copeland,Nancy A. Jenkins,Alexander Varshavsky +9 more
TL;DR: The cloning of Ubr1 makes possible the construction of UBR1-lacking mouse strains, a prerequisite for the functional understanding of the mammalian N-end rule pathway.
Ubiquitin-mediated protein degradation: The early days The ubiquitin system
TL;DR: The degradation of tyrosine aminotransferase in cultured hepatoma cells is completely arrested by inhibitors of cellular energy production, such as fluoride or azide, which confirmed and extended the previous observations of Simpson on the energy dependence of the release of amino acids from liver slices.