A
Alexander Varshavsky
Researcher at California Institute of Technology
Publications - 226
Citations - 37652
Alexander Varshavsky is an academic researcher from California Institute of Technology. The author has contributed to research in topics: N-end rule & Ubiquitin. The author has an hindex of 95, co-authored 222 publications receiving 35798 citations. Previous affiliations of Alexander Varshavsky include Harvard University & Massachusetts Institute of Technology.
Papers
More filters
Journal ArticleDOI
Basic Medical Research Award. The ubiquitin system.
TL;DR: The ubiquitin system plays important roles in the control of numerous processes, including cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation, and endocytosis as mentioned in this paper.
Journal ArticleDOI
In Vivo Half-Life of a Protein is a Function of its Amino-Terminal Residue
TL;DR: The recognition of an amino-terminal residue in a protein may mediate both the metabolic stability of the protein and the potential for regulation of its stability as predicted by the N-end rule.
Journal ArticleDOI
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.
Vincent Chau,John W. Tobias,Andreas Bachmair,Andreas Bachmair,David Marriott,David J. Ecker,David K. Gonda,Alexander Varshavsky +7 more
TL;DR: The experiments with ubiquitin mutated at its Lys48 residue indicate that the multiubiquitin chain in a targeted protein is essential for the degradation of the protein.
Journal ArticleDOI
The N-end rule: functions, mysteries, uses
TL;DR: The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue and is discussed, and its applications are considered.
Journal ArticleDOI
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses
TL;DR: Results indicate that UBI4 is specifically required for the resistance of cells to stress, and that ubiquitin is an essential component of the stress response system.