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Axel Methner
Researcher at University of Mainz
Publications - 95
Citations - 4922
Axel Methner is an academic researcher from University of Mainz. The author has contributed to research in topics: Oxidative stress & Endoplasmic reticulum. The author has an hindex of 36, co-authored 93 publications receiving 4051 citations. Previous affiliations of Axel Methner include University of Hamburg & University of Düsseldorf.
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Journal ArticleDOI
The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities
Jan Lewerenz,Sandra J. Hewett,Ying Huang,Maria P. Lambros,Peter W. Gout,Peter W. Kalivas,Ann Massie,Ilse Julia Smolders,Axel Methner,Mathias Pergande,Sylvia B. Smith,Vadivel Ganapathy,Pamela Maher +12 more
TL;DR: By phylogenetic analysis, it is shown that system x(c)(-) is a rather evolutionarily new amino acid transport system and its diverse roles in the regulation of the immune response, in various aspects of cancer and in the eye and the CNS are highlighted.
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Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands
Patrick Joost,Axel Methner +1 more
TL;DR: The authors' trees show the overall relationship of 277 GPCRs with emphasis on orphan receptors, and may prove valuable for identification of the natural ligands of orphan receptors as their relation to receptors with known ligands becomes more evident.
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Effects of dimethyl fumarate on neuroprotection and immunomodulation
Philipp Albrecht,Imane Bouchachia,Norbert Goebels,Nadine Henke,Harald H. Hofstetter,Andrea Issberner,Zsuzsa Kovacs,Jan Lewerenz,Dmitrij Lisak,Pamela Maher,Anne-Kathrin Mausberg,Kim Quasthoff,Corinna Zimmermann,Hans-Peter Hartung,Axel Methner +14 more
TL;DR: These results suggest that immunomodulatory concentrations of dimethyl fumarate can reduce oxidative stress without altering neuronal network activity.
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Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.
TL;DR: It is suggested that oxytosis and ferroptosis should be regarded as two names for the same cell death pathway, and the potential physiological relevance of oxyTosis/ferroPTosis in multiple neurological diseases is described.
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Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro
Jan Lewerenz,Philipp Albrecht,Mai-Ly Tran Tien,Nadine Henke,Saravanan Karumbayaram,Harley I. Kornblum,Martina Wiedau-Pazos,Dave Schubert,Pamela Maher,Axel Methner +9 more
TL;DR: It is shown that ceftriaxone also protects fibroblasts and the hippocampal cell line HT22, which are not sensitive to excitotoxicity, against oxidative glutamate toxicity, where extracellular glutamate blocks cystine import via the glutamate/cystine‐antiporter system xc−.