V
Vadivel Ganapathy
Researcher at Texas Tech University Health Sciences Center
Publications - 539
Citations - 36373
Vadivel Ganapathy is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Amino acid & Transporter. The author has an hindex of 97, co-authored 526 publications receiving 32829 citations. Previous affiliations of Vadivel Ganapathy include Health Science University & Christian Medical College & Hospital.
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Journal ArticleDOI
Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
Nagendra Singh,Ashish Gurav,Sathish Sivaprakasam,Evan Brady,Ravi Padia,Huidong Shi,Muthusamy Thangaraju,Puttur D. Prasad,Santhakumar Manicassamy,David H. Munn,Jeffrey R. Lee,Stefan Offermanns,Vadivel Ganapathy +12 more
TL;DR: This paper showed that GPR109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells.
Journal ArticleDOI
Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.
Sammanda Ramamoorthy,Andrea L. Bauman,Kim R. Moore,Hong Han,Teresa L. Yang-Feng,Albert S. Chang,Vadivel Ganapathy,Randy D. Blakely +7 more
TL;DR: A Na(+)- and Cl(-)-coupled serotonin (5-hydroxytryptamine, 5HT) transporter is expressed on human neuronal, platelet, placental, and pulmonary membranes and sequence analysis reveals a 630-amino acid open reading frame bearing 92% identity to the cloned rat brain 5HT transporter.
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Expression cloning of a mammalian proton-coupled oligopeptide transporter
You Jun Fei,You Jun Fei,Yoshikatsu Kanai,Yoshikatsu Kanai,Stephan Nussberger,Vadivel Ganapathy,Frederick H. Leibach,Michael F. Romero,Satish K. Singh,Walter F. Boron,Matthias A. Hediger +10 more
TL;DR: The cloning and functional characterization of a H+-coupled transporter of oligopeptides and peptide-derived antibiotics from rabbit small intestine is reported, and the PepT1 primary structure is the first reported for a proton-Coupled organic solute transporter in vertebrates.
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Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
TL;DR: This review focuses on three groups of nutrient transporters relevant to cancer: glucosetransporters, lactate transportters, and amino acid transporter, which are related to amino acid nutrition.
Journal ArticleDOI
The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities
Jan Lewerenz,Sandra J. Hewett,Ying Huang,Maria P. Lambros,Peter W. Gout,Peter W. Kalivas,Ann Massie,Ilse Julia Smolders,Axel Methner,Mathias Pergande,Sylvia B. Smith,Vadivel Ganapathy,Pamela Maher +12 more
TL;DR: By phylogenetic analysis, it is shown that system x(c)(-) is a rather evolutionarily new amino acid transport system and its diverse roles in the regulation of the immune response, in various aspects of cancer and in the eye and the CNS are highlighted.