Axel Zeeck

TL;DR: The systematic alteration of easily accessible cultivation parameters in order to increase the number of secondary metabolites available from one microbial source is investigated and the OSMAC approach seems to be a useful tool to detect those metabolites that are postulated to be the final products of an amazing number of typical secondary metabolites gene clusters identified in several microorganisms.

TL;DR: Binding of J-concanolide A to subunit c was prevented in a concentration-dependent manner by concanamycin A, indicating that labeling was specific, and binding was also prevented by the plecomacrolides bafilomycin A1 and B1, respectively.

TL;DR: A new anthraquinone glycoside, emodin-6-O-beta-D-glucopyranoside, and a new simple halogenated flavan-3-ol, 6-chlorocatechin, have been isolated from the roots of Rumex patientia L. together with seven known phenolic compounds.

TL;DR: The myxobacterial antibiotics archazolid and apicularen are highly efficient and specific novel inhibitors of V-ATPases.

TL;DR: The colored urdamycins A to F, six new angucycline antibiotics produced by Streptomyces fradiae strain Tu 2717, were detected by chemical screening and are biologically active against Gram-positive bacteria and stem cells of murine L1210 leukemia.