A
Aya Sasaki
Researcher at University of Toronto
Publications - 20
Citations - 4506
Aya Sasaki is an academic researcher from University of Toronto. The author has contributed to research in topics: Offspring & DNA methylation. The author has an hindex of 8, co-authored 18 publications receiving 4145 citations. Previous affiliations of Aya Sasaki include McGill University & Douglas Mental Health University Institute.
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Journal ArticleDOI
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
Journal ArticleDOI
Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats
Patrick O. McGowan,Patrick O. McGowan,Patrick O. McGowan,Matthew Suderman,Aya Sasaki,Aya Sasaki,Aya Sasaki,Tony Chieh-Ting Huang,Michael Hallett,Michael J. Meaney,Moshe Szyf,Moshe Szyf +11 more
TL;DR: These epigenetic and transcriptional profiles constitute the first tiling microarray data set exploring the relationship between epigenetic modifications and RNA expression in both protein coding and non-coding regions across a chromosomal locus in the mammalian brain.
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Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain
Patrick O. McGowan,Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Tony Chieh-Ting Huang,Alexander Unterberger,Matthew Suderman,Carl Ernst,Michael J. Meaney,Michael J. Meaney,Gustavo Turecki,Moshe Szyf +11 more
TL;DR: This is the first study to show aberrant regulation of the protein synthesis machinery in the suicide brain and the data implicate the epigenetic modulation of rRNA in the pathophysiology of suicide.
Journal ArticleDOI
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
Matthew Suderman,Patrick O. McGowan,Aya Sasaki,Tony Chieh-Ting Huang,Michael Hallett,Michael J. Meaney,Gustavo Turecki,Moshe Szyf,Moshe Szyf +8 more
TL;DR: DNA methylation profiles spanning 6.5 million base pairs centered at the NR3C1 gene in the hippocampus of humans who experienced abuse as children and nonabused controls are presented to provide support for an analogous cross-species epigenetic regulatory response at the level of the genomic region to early life experience.
Journal ArticleDOI
Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood
TL;DR: The data indicate that the dietary environment during development programs glucocorticoid signaling pathways in limbic areas relevant for the regulation of HPA function and anxiety behavior are relevant.