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Aykut Aksit
Researcher at Columbia University
Publications - 15
Citations - 200
Aykut Aksit is an academic researcher from Columbia University. The author has contributed to research in topics: Round window & Perforation (oil well). The author has an hindex of 6, co-authored 10 publications receiving 96 citations.
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Journal ArticleDOI
In-vitro perforation of the round window membrane via direct 3-D printed microneedles
Aykut Aksit,Arteaga Daniel N,Miguel Arriaga,Xun Wang,Hirobumi Watanabe,Karen E. Kasza,Anil K. Lalwani,Jeffrey W. Kysar +7 more
TL;DR: Results establish a foundation for the use of Two-Photon Polymerization lithography as a means to fabricate microneedles to perforate the RWM and other similar membranes.
Journal ArticleDOI
Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs
Betsy Szeto,Aykut Aksit,Chris Valentini,Michelle Yu,Emily G. Werth,Shahar Goeta,Chuanning Tang,Lewis M. Brown,Elizabeth S. Olson,Jeffrey W. Kysar,Anil K. Lalwani +10 more
TL;DR: Hollow microneedles can facilitate aspiration of perilymph across the RWM at a quality and volume adequate for proteomic analysis without causing permanent anatomic or physiologic dysfunction.
Journal ArticleDOI
Drug delivery device for the inner ear: ultra-sharp fully metallic microneedles
Aykut Aksit,Shruti Rastogi,Maria L Nadal,Amber M Parker,Anil K. Lalwani,Alan C. West,Jeffrey W. Kysar +6 more
TL;DR: This microneedle has the potential literally of opening the RWM for enhanced drug delivery into the inner ear and is developed using a hybrid additive manufacturing method using two-photon lithography and electrochemical deposition to fabricate ultra-sharp gold-coated coppermicroneedles with these attributes.
Journal ArticleDOI
3D-Printed Microneedles Create Precise Perforations in Human Round Window Membrane in Situ.
Harry Chiang,Michelle Yu,Aykut Aksit,Wenbin Wang,Sagit Stern-Shavit,Jeffrey W. Kysar,Anil K. Lalwani +6 more
TL;DR: 3D-printed microneedles can create precise perforations in the HRWM without damaging intracochlear structures, and have many potential applications ranging from aspiration of cochlear fluids using a lumenized needle for diagnosis and creating portals for therapeutic delivery into the inner ear.
Journal ArticleDOI
Anatomical and Functional Consequences of Microneedle Perforation of Round Window Membrane.
Michelle Yu,Arteaga Daniel N,Aykut Aksit,Harry Chiang,Elizabeth S. Olson,Jeffrey W. Kysar,Anil K. Lalwani +6 more
TL;DR: Microneedles have the potential to mediate safe and effective intracochlear access for diagnosis and treatment of inner ear disease and can create a temporary microperforation in the RWM without causing significant anatomic or physiologic dysfunction.